tert-Butyl 2-isocyano-3-methylbutyrate
Tert-Butyl 2-isocyano-3-methylbutyrate (CAS: 32755-42-3) is a versatile organic compound with the linear formula (CH3)2CHCH(NC)COOC(CH3)3 and a molecular weight of 183.25 g/mol. This isocyanide derivative is a key building block utilised in advanced chemical synthesis. It finds application in multicomponent reactions, notably the Ugi reaction, enabling the efficient construction of complex molecular architectures. Tech Serve Solutions supplies this reagent for research and development purposes.
- IUPAC
- DL-Valine tert-butyl ester isocyanide
- Synonyms
- DL-Valine tert-butyl ester isocyanide
Ugi Reaction
Tert-Butyl 2-isocyano-3-methylbutyrate is a valuable component in the Ugi four-component reaction. This reaction efficiently synthesizes alpha-adducts from an aldehyde or ketone, a primary amine, a carboxylic acid, and an isocyanide.
Multicomponent Reactions
This isocyanide serves as a crucial building block in various multicomponent reactions. These reactions are highly convergent, allowing for the rapid assembly of complex molecular structures from simpler precursors in a single synthetic operation.
Organic Synthesis
As an organic building block, tert-Butyl 2-isocyano-3-methylbutyrate is instrumental in the synthesis of diverse organic molecules. Its isocyano functional group offers unique reactivity pathways for creating novel chemical entities.
| Molecular weight | 183.25 |
|---|---|
| Linear formula | (CH3)2CHCH(NC)COOC(CH3)3 |
| Assay | ≥97.0% (GC) |
| Refractive index | n20/D 1.424 |
| Storage temperature | −20°C |
| Application | tert-Butyl 2-isocyano-3-methylbutyrate may be used in 4-component reaction, Ugi reaction. |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H332Harmful if inhaled
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 10-20/21/22 |
| Safety statements (S) | 16-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is tert-Butyl 2-isocyano-3-methylbutyrate used for?
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Tert-Butyl 2-isocyano-3-methylbutyrate (CAS: 32755-42-3) is used as a building block in chemical synthesis, particularly in multicomponent reactions like the Ugi reaction.
What is the CAS number and formula for tert-Butyl 2-isocyano-3-methylbutyrate?
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The CAS number is 32755-42-3, and the linear formula is (CH3)2CHCH(NC)COOC(CH3)3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies tert-Butyl 2-isocyano-3-methylbutyrate with an assay of ≥97.0% (GC). This product is not intended for pharmaceutical, food, or other regulated applications unless explicitly stated.
What are the safety considerations for handling tert-Butyl 2-isocyano-3-methylbutyrate?
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Warning: This compound is harmful if swallowed, in contact with skin, or if inhaled (H302-H312-H332). Appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator, must be worn. It should be stored at -20°C.
How is tert-Butyl 2-isocyano-3-methylbutyrate packed and shipped?
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Tert-Butyl 2-isocyano-3-methylbutyrate is carefully packed according to international shipping regulations for chemicals and is exported globally by Tech Serve Solutions.
How can I request a sample or quote for tert-Butyl 2-isocyano-3-methylbutyrate?
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To request a sample or quote, please use the contact form on our website or contact our sales department directly with your specific requirements.
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