tert-Butoxy(chloro)diphenylsilane
tert-Butoxy(chloro)diphenylsilane (CAS: 17922-24-6) is a silicon-based organic compound with the molecular formula C16H19ClOSi and a molecular weight of 290.86 g/mol. It serves as a valuable reagent in chemical synthesis, particularly in protection and derivatization strategies. Its properties make it suitable for applications requiring selective functional group modification in complex molecular structures.
- IUPAC
- tert-Butoxy-diphenylchlorosilane
- Synonyms
- tert-Butoxy-diphenylchlorosilane

Protecting Group Chemistry
This silane derivative is utilised as a protecting group reagent for alcohols and other nucleophilic functional groups during multi-step organic syntheses. The tert-butoxy(diphenyl)silyl ether is generally stable under various reaction conditions but can be cleaved selectively when required.
Derivatization Agent
It can be employed as a derivatizing agent to modify the properties of target molecules, aiding in their purification, characterisation, or subsequent reactions. The introduction of the bulky silyl group can alter solubility and chromatographic behaviour.
Intermediate in Organic Synthesis
The compound functions as a key intermediate in the synthesis of more complex organosilicon compounds or other fine chemicals. Its reactive Si-Cl bond allows for further functionalisation via nucleophilic substitution reactions.
| Molecular weight | 290.86 |
|---|---|
| Empirical formula | C16H19ClOSi |
| Assay | ≥97.0% (GC) |
| Boiling point | 130-135 °C/0.1 mmHg |
| Density | 1.076 g/mL at 20 °C(lit.) |
| Refractive index | n20/D 1.539 |
| Storage temperature | −20°C |
| Contains / stabiliser | ~0.5% CaCO3 as stabilizer |


Hazard statements
- H226Flammable liquid and vapour
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 56 °C / 132.8 °F |
| Transport (UN / ADR) | UN 2986 3(8) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is tert-Butoxy(chloro)diphenylsilane used for?
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tert-Butoxy(chloro)diphenylsilane is primarily used as a protecting group reagent for alcohols and as an intermediate in organic synthesis, particularly in strategies involving silicon-based chemistry.
What is the CAS number and formula for tert-Butoxy(chloro)diphenylsilane?
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The CAS number is 17922-24-6, and the empirical formula (Hill notation) is C16H19ClOSi.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies tert-Butoxy(chloro)diphenylsilane with an assay of ≥97.0% (GC). TSS does not represent this product as USP, BP, or EP grade.
How should tert-Butoxy(chloro)diphenylsilane be handled?
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tert-Butoxy(chloro)diphenylsilane is a corrosive and flammable liquid. Handle with extreme care in a well-ventilated area, using appropriate personal protective equipment including gloves, goggles, face shield, and respiratory protection. Store at -20°C.
Is tert-Butoxy(chloro)diphenylsilane a controlled substance?
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The provided data does not indicate that tert-Butoxy(chloro)diphenylsilane is a controlled substance.
How is this chemical packed, shipped, and exported?
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As a specialist global supplier and exporter, Tech Serve Solutions adheres to all relevant regulations for packing, shipping, and exporting chemicals like tert-Butoxy(chloro)diphenylsilane, ensuring safe and compliant delivery worldwide.
How can I request a sample or quote for tert-Butoxy(chloro)diphenylsilane?
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Please contact our sales department directly via our website or by phone to request a sample or obtain a quotation for tert-Butoxy(chloro)diphenylsilane.
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