Sodium selenite
Sodium selenite (CAS: 10102-18-8; Formula: Na2SeO3; Molar Mass: 172.94 g/mol) is an inorganic salt recognised for its antioxidant properties. It serves as a vital selenium source in biological research, playing a role in crucial selenoproteins like glutathione peroxidase. Utilised in cell culture and cancer research, it can influence cell proliferation and gene expression. Its applications extend to functional foods and synthetic chemistry, making it a versatile reagent.
Biological Research and Cell Culture
Sodium selenite is an essential trace element source for biological studies, particularly in cell culture applications where it's used at concentrations like 0.005 mg/L. It contributes to the function of vital selenoproteins, including glutathione peroxidase, aiding in cellular defence against oxidative stress.
Antioxidant and Nutritional Research
As an antioxidant, it is investigated for its role in combating oxidative damage and influencing cellular processes. Its significance in nutrition research stems from selenium's essentiality in various physiological functions.
Chemical Synthesis
Sodium selenite serves as a reagent in chemical synthesis, contributing selenium to various chemical transformations and the development of novel compounds.
Cancer Research
This compound is employed in cancer research to study its effects on cell proliferation, gene expression, and potential induction of apoptosis by altering mitochondrial membrane potentials.
| Molecular weight | 172.94 |
|---|---|
| Linear formula | Na2SeO3 |
| Assay | ≥98% |
| Form | powder |
| Loss on drying | ≤0.5% loss on drying, 200 °C |
| Application | Sodium selenite is commonly used as a source of selenium in biological research, where selenium is an essential trace element that is normally provided by serum. Selenium is present in selenoproteins such as glutathione peroxidase and thioredoxin reductase, which contain the selenium analog of cysteine, selenocysteine. In particular, glutathione peroxidase has a role in detoxification in vivo as a scavenger of peroxides. Sodium selenite has been utilized in studies of cell proliferation and cancer research. It has been used to alter gene expression in HepG2 cells as analyzed by cDNA microarrays. Sodium selenite can inhibit zinc finger protein/DNA interactions. Sodium selenite has been shown to alter mitochondrial membrane potentials and thus potentially contribute to apoptosis.This product is cell culture tested (0.005 mg/L) and is appropriate for use in cell culture applications. |
| Suitability | suitable for cell culture |
| Melting point | >350 °C(lit.) |
Hazard statements
- H300Fatal if swallowed
- H317May cause an allergic skin reaction
- H331Toxic if inhaled
- H411Toxic to aquatic life with long-lasting effects
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P264Wash thoroughly after handling
- P273Avoid release to the environment
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P311Call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 2630 6.1/PG 1 |
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | T+,N |
| Risk statements (R) | 23-28-31-43-51/53 |
| Safety statements (S) | 28-36/37-45-61 |
| Supplemental hazards | Contact with acids liberates toxic gas. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Product Line | BioReagent |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Sodium selenite used for?
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Sodium selenite is primarily used as a source of selenium in biological research and cell culture, for its antioxidant properties, in nutritional research, chemical synthesis, and cancer research.
What is the CAS number and formula for Sodium selenite?
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The CAS number for Sodium selenite is 10102-18-8, and its chemical formula is Na2SeO3.
What grade and purity does Tech Serve Solutions supply for Sodium selenite?
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Tech Serve Solutions supplies Sodium selenite with an assay of ≥98% and a loss on drying of ≤0.5% at 200 °C. This product is tested for cell culture suitability. We do not represent it as USP, BP, or EP grade.
How should Sodium selenite be handled safely?
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Sodium selenite is toxic if swallowed (H300), harmful if inhaled (H331), causes skin irritation (H317), and is toxic to aquatic life with long-lasting effects (H411). It releases toxic gas when in contact with acids. Appropriate personal protective equipment, including eyeshields, gloves, and respiratory protection (type N100 US/P3 EN143 filters), must be used. Handle in a well-ventilated area and avoid contact with acids.
How is Sodium selenite supplied and exported?
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Sodium selenite is supplied as a powder and exported in compliance with all relevant transport regulations, including UN 2630, Hazard Class 6.1, Packing Group I.
How can I request a quote or sample of Sodium selenite?
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To request a quote or a sample of Sodium selenite, please contact our sales team through the TSS website or your dedicated account manager.
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