Sodium iodoacetate
Sodium iodoacetate (CAS 305-53-3) is a valuable organic building block with the linear formula ICH₂COONa and a molecular weight of 207.93. It functions as a critical reagent for modifying cysteine residues within proteins, particularly in protein sequencing. This modification prevents the oxidation of sulfhydryl side chains, ensuring accurate analysis. Tech Serve Solutions supplies this chemical for research and synthesis applications.
- IUPAC
- Iodoacetic acid sodium salt
- Synonyms
- Iodoacetic acid sodium salt
Protein Modification Reagent
Sodium iodoacetate is used to selectively alkylate cysteine residues in proteins, forming stable thioether linkages. This is crucial for preventing unwanted oxidation of free sulfhydryl groups during protein analysis and sequencing.
Protein Sequencing
Historically, it has been employed in protein sequencing methodologies to protect cysteine side chains. An example includes its use in sequencing bovine insulin, where it prevented oxidation of critical thiol groups.
Chemical Synthesis
As an organic building block, sodium iodoacetate can be utilised in various synthetic routes. Its reactive nature makes it a useful intermediate in the preparation of more complex organic molecules.
| Molecular weight | 207.93 |
|---|---|
| Linear formula | ICH2COONa |
| Assay | ≥98.0% (NT) |
| Solubility | H2O: soluble0.5 M, clear, colorless |
| Storage temperature | −20°C |
| Impurities tested | ≤0.0005% Phosphorus (P)≤0.1% Insoluble matter |
| Application | Reagent for the modification of cysteine residues in proteins. Used in protein sequencing (including by Sanger in sequencing bovine insulin) to prevent oxidation of -SH sidechains. |
| Melting point | 208 °C (dec.)(lit.) |
Hazard statements
- H301Toxic if swallowed
- H315Causes skin irritation
- H318Causes serious eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 25-37/38-41 |
| Safety statements (S) | 26-39-45 |
| Cation traces | Al: ≤0.0005%Ca: ≤0.001%Cu: ≤0.001%Fe: ≤0.0005%K: ≤0.02%Mg: ≤0.0005%NH4+: ≤0.05%Pb: ≤0.001%Zn: ≤0.0005% |
| Anion traces | sulfate (SO42-): ≤0.05% |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Sodium iodoacetate used for?
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Sodium iodoacetate is primarily used as a reagent for modifying cysteine residues in proteins, preventing their oxidation and aiding in protein sequencing. It also serves as a building block in chemical synthesis.
What is the CAS number and formula for Sodium iodoacetate?
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The CAS number for Sodium iodoacetate is 305-53-3, and its linear formula is ICH₂COONa.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Sodium iodoacetate with an assay of ≥98.0% (NT). We do not represent this product as USP, BP, or EP grade.
How should Sodium iodoacetate be handled safely?
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Sodium iodoacetate is a dangerous substance (GHS05, GHS06, Danger) that can cause severe eye damage (H318), skin irritation (H315), respiratory irritation (H335), and is toxic if swallowed (H301). Always use appropriate personal protective equipment, including eyeshields, face shields, gloves, and a P2 respirator cartridge.
Is Sodium iodoacetate shipped internationally?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including Sodium iodoacetate, which can be packed and shipped according to international regulations (UN 2811 6.1 / PGIII).
How can I request a quote or sample?
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To request a quote or sample of Sodium iodoacetate, please contact our sales team through the website or by calling our customer service line.
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