Sodium diformylamide
Sodium diformylamide (CAS 18197-26-7), with the molecular formula (HCO)₂NNa and a molecular weight of 95.03 g/mol, is a versatile chemical reagent. It functions as a reactant in various organic synthesis pathways. Its primary applications involve the preparation of complex heterocyclic compounds, including functionalized benzazoles and α-ketoheterocycles, as well as serving as a precursor in the synthesis of novel pharmaceutical intermediates and ligands.
- IUPAC
- Diformylimide sodium salt
- Synonyms
- Diformylimide sodium salt
Synthesis of Functionalized Benzazoles
Sodium diformylamide serves as a key reactant in the preparation of various functionalized condensed benzazoles. These heterocyclic compounds are of interest in medicinal chemistry research.
Preparation of α-ketoheterocycles
This compound is utilised in the synthesis of α-ketoheterocycles, which have been investigated as potential inhibitors for specific enzymes like Leishmania mexicana cysteine protease CPB.
Intermediate in Pharmaceutical Synthesis
It acts as a reactant in the Bucherer-Bergs hydantoin synthesis pathway, leading to intermediates such as INOS inhibitor PHA-399733. It is also used in the development of antibiotic resistance inhibitor analogues.
Ligand Synthesis
Sodium diformylamide is employed in the synthesis of BINOL- and H8-BINOL-based aryl phosphites. These compounds function as valuable ligands in palladium-catalyzed asymmetric reactions, including allylation and amination.
Precursor for Integrin Antagonists
The compound serves as a precursor in the development of molecules designed as αVβ3 integrin antagonists, which are relevant in certain therapeutic research areas.
| Molecular weight | 95.03 |
|---|---|
| Linear formula | (HCO)2NNa |
| Assay | ≥97.0% (NT) |
| Application | Reactant for preparation of:• Functionalized condensed benzazoles1• α-ketoheterocycles as inhibitors of Leishmania mexicana cysteine protease CPB2• INOS inhibitor PHA-399733 via Bucherer-Bergs hydantoin synthesis3• Antibiotic resistance (C β-lactamase AmpC) inhibitor analogues, with improved cell permeability properties4• BINOL- and H8-BINOL-based aryl phosphites as ligands in palladium-catalyzed asymmetric allylation and amination reactions5• Precursors of αVβ3 integrin antagonists6 |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Sodium diformylamide used for?
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Sodium diformylamide is used as a reactant in organic synthesis, particularly for preparing functionalized benzazoles, α-ketoheterocycles, pharmaceutical intermediates like INOS inhibitor PHA-399733, antibiotic resistance inhibitor analogues, and ligands for catalysis.
What is the CAS number and formula for Sodium diformylamide?
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The CAS number is 18197-26-7 and the linear formula is (HCO)₂NNa.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Sodium diformylamide with a purity of ≥97.0% (NT). This is a technical or research grade material and TSS does not represent it as USP, BP, EP, or pharmacopoeia grade.
What are the safety and handling precautions for Sodium diformylamide?
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Sodium diformylamide is a Warning substance that causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Recommended personal protective equipment includes a dust mask (type N95 US), eyeshields, and gloves. Handle in a well-ventilated area.
How is Sodium diformylamide packed and shipped?
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Tech Serve Solutions professionally packs and exports chemicals globally. Specific packaging details will be provided upon inquiry and are designed to maintain product integrity during transit.
How can I request a sample or quote for Sodium diformylamide?
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To request a sample or a quote for Sodium diformylamide, please contact our sales team through the website or by phone, providing your specific requirements.
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