SIS3
SIS3 (CAS: 521984-48-5), with the molecular formula C28H27N3O3 · HCl and a molecular weight of 489.99, is a bioactive small molecule. This yellow powder is primarily utilised in research settings for its role in cell signaling pathways, particularly related to kinase biology. It serves as a valuable tool for scientists investigating cellular processes and potential therapeutic targets in fields such as cell biology and neuroscience.
- IUPAC
- (2E)-1-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-propenone hydrochloride

Cellular Signalling Research
SIS3 is employed in biochemical and cellular assays to investigate signalling pathways involving kinases. Its specific inhibitory properties make it useful for dissecting the roles of certain kinase families in cellular functions.
Drug Discovery and Development
As a bioactive small molecule, SIS3 can serve as a lead compound or research tool in the early stages of drug discovery. Researchers use it to understand disease mechanisms and to screen for potential therapeutic agents.
Neuroscience Research Tool
Given its involvement in cell signaling pathways, SIS3 finds application in neuroscience research to study neuronal function and development. It can help elucidate the role of specific signalling cascades in neural processes.
| Molecular weight | 489.99 |
|---|---|
| Empirical formula | C28H27N3O3 · HCl |
| Assay | ≥98% (HPLC) |
| Form | powder |
| Colour | yellow |
| Solubility | H2O: DMSO: >20 mg/mL |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is SIS3 used for?
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SIS3 is primarily used in research for investigating cellular signalling pathways, particularly those involving kinases, and as a tool in drug discovery and neuroscience research.
What is the CAS number and molecular formula for SIS3?
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The CAS number for SIS3 is 521984-48-5, and its molecular formula is C28H27N3O3 · HCl.
What grade and purity does Tech Serve Solutions supply for SIS3?
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Tech Serve Solutions supplies SIS3 with a purity of ≥98% (HPLC). We do not represent this product as USP, BP, or EP grade.
How should SIS3 be handled and stored?
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SIS3 should be handled with appropriate personal protective equipment, including eyeshields, gloves, and a type N95 (US) or P1 (EN143) respirator filter. It is recommended to store the compound at 2-8°C.
Is SIS3 a controlled substance?
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The provided data does not indicate that SIS3 is a controlled substance.
How is SIS3 packed, shipped, and exported?
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Tech Serve Solutions professionally packs, ships, and exports SIS3 globally, adhering to all necessary regulations for chemical transport.
How can I request a sample or quote for SIS3?
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To request a sample or quote for SIS3, please contact our sales team through the website or by phone.
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