(S)-SIPHOS-PE
(S)-SIPHOS-PE (CAS: 500997-70-6), with the molecular formula C33H32NO2P and a molecular weight of 505.59 g/mol, is a chiral ligand crucial for asymmetric synthesis. Its specific optical activity, [α]22/D −65.0°, in chloroform indicates its utility in enantioselective transformations. This phosphoramidite derivative is employed in catalytic processes where precise stereochemical control is required, facilitating the synthesis of chiral molecules.
- IUPAC
- (11aS)-(−)-10,11,12,13-Tetrahydrodiindeno[7,1-de:1′, 7′-fg][1,3,2]dioxaphosphocin-5-bis[(R)-1-phenylethyl]amine,N-Di[(R)-1-phenylethyl]-[(S)-1,1′-spirobiindane-7,7′-diyl]-phosphoramidite
Asymmetric Catalysis
As a chiral phosphoramidite ligand, (S)-SIPHOS-PE is instrumental in transition metal-catalysed asymmetric reactions. It enables the enantioselective formation of carbon-carbon and carbon-heteroatom bonds, essential in pharmaceutical and fine chemical synthesis.
Stereoselective Synthesis
This ligand is employed to achieve high levels of enantioselectivity in various organic transformations. Its structure is designed to coordinate with metal centres, directing the stereochemical outcome of reactions.
Ligand for Metal Complexes
(S)-SIPHOS-PE functions as a ligand in the formation of catalytic metal complexes. These complexes are highly effective in promoting stereospecific reactions with excellent chiral induction.
| Molecular weight | 505.59 |
|---|---|
| Empirical formula | C33H32NO2P |
| Assay | 97% |
| Optical activity | [α]22/D −65.0°, c = 1 in chloroform |
| Storage temperature | −20°C |
| Melting point | 120-125 °C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (S)-SIPHOS-PE used for?
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(S)-SIPHOS-PE is primarily used as a chiral ligand in asymmetric synthesis, particularly in transition metal-catalysed enantioselective reactions where precise stereochemical control is essential.
What are the CAS number and formula for (S)-SIPHOS-PE?
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The CAS number for (S)-SIPHOS-PE is 500997-70-6, and its molecular formula is C33H32NO2P.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (S)-SIPHOS-PE with a minimum assay of 97%. This product is intended for research and chemical synthesis purposes and is not represented as USP, BP, or EP grade.
What are the safety and handling precautions for (S)-SIPHOS-PE?
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(S)-SIPHOS-PE is classified as a Warning with hazards including skin irritation (H315), eye irritation (H319), and respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves, should be used. Handle in a well-ventilated area and avoid dust formation.
How is (S)-SIPHOS-PE packed and shipped?
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This chemical is typically stored at −20°C. Packaging and shipping procedures adhere to international regulations for the transport of chemicals, ensuring product integrity and safety during transit and export.
How can I request a sample or quote for (S)-SIPHOS-PE?
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To request a sample or obtain a quote for (S)-SIPHOS-PE, please contact the Tech Serve Solutions sales team through our website or by calling our customer service line.
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