(S)-2-(Trifluoromethyl)piperidine
(S)-2-(Trifluoromethyl)piperidine (CAS: 154727-51-2; Formula: C6H10F3N; MW: 153.15) is a valuable chiral building block characterised by its trifluoromethyl substituent on the piperidine ring. This fluorinated heterocyclic compound plays a crucial role in asymmetric synthesis and chemical research. Its defined stereochemistry makes it a sought-after intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical industries where precise molecular architecture is paramount for biological activity.
Chiral Synthesis
Serves as a stereochemically defined building block for the synthesis of enantiomerically pure target molecules. Its incorporation allows for the introduction of both a piperidine core and a trifluoromethyl group in a controlled chiral manner.
Pharmaceutical Intermediates
Utilised in the development of novel pharmaceutical agents. The trifluoromethyl group can influence lipophilicity, metabolic stability, and binding affinity, making it an attractive moiety in drug design.
Agrochemical Research
Employed in the synthesis of new agrochemicals, such as pesticides and herbicides. The presence of fluorine can enhance efficacy and alter the environmental profile of active ingredients.
Organic Synthesis Reagent
A versatile reagent in general organic synthesis, enabling access to a range of functionalised piperidine derivatives. Its reactivity can be leveraged in various coupling and derivatisation reactions.
| Molecular weight | 153.15 |
|---|---|
| Empirical formula | C6H10F3N |
| Assay | 97% |
| Density | 1.161 g/mL at 25 °C |
| Refractive index | n20/D 1.391 |
| Optical activity | [α]22/D -14.4°, c = 0.5% in methanol |
Hazard statements
- H226Flammable liquid and vapour
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H400Very toxic to aquatic life
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P273Avoid release to the environment
- P305IF IN EYES
| Flash point | 26 °C / 78.8 °F |
|---|---|
| Transport (UN / ADR) | UN 1993C 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn,N |
| Risk statements (R) | 10-22-36/37/38-50 |
| Safety statements (S) | 26-36/37/39-45-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (S)-2-(Trifluoromethyl)piperidine used for?
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(S)-2-(Trifluoromethyl)piperidine is primarily used as a chiral building block in asymmetric synthesis, particularly in the development of pharmaceutical intermediates and agrochemicals, owing to its unique fluorinated heterocyclic structure.
What is the CAS number and chemical formula for (S)-2-(Trifluoromethyl)piperidine?
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The CAS number is 154727-51-2 and the chemical formula is C6H10F3N.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (S)-2-(Trifluoromethyl)piperidine with an assay of 97%. This product is supplied for research and chemical synthesis purposes and is not represented as USP, BP, EP, or pharmacopoeia grade.
How should (S)-2-(Trifluoromethyl)piperidine be handled?
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This compound is a flammable liquid and vapour (H226), harmful if swallowed (H302), and causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). It is also very toxic to aquatic life (H400). Handle in a well-ventilated area, wear appropriate protective equipment (gloves, eye protection), and avoid release into the environment. Store away from heat and ignition sources.
Is (S)-2-(Trifluoromethyl)piperidine a controlled substance?
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Based on the provided data, there is no indication that (S)-2-(Trifluoromethyl)piperidine is a controlled substance.
How is (S)-2-(Trifluoromethyl)piperidine packed, shipped, and exported?
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(S)-2-(Trifluoromethyl)piperidine is classified under UN 1993, Packing Group III, for transportation. Tech Serve Solutions, as a global supplier, handles international shipping and export in compliance with relevant regulations.
How can I request a sample or quote for (S)-2-(Trifluoromethyl)piperidine?
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To request a sample or a quotation, please use the contact form on the Tech Serve Solutions website or contact our sales department directly with your inquiry, referencing the product name and CAS number.
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