(S)-(−)-2-(Trifluoroacetamido)succinic anhydride

CAS 777-33-3C6H4F3NO4Chemical Synthesis

(S)-(−)-2-(Trifluoroacetamido)succinic anhydride (CAS: 777-33-3, C6H4F3NO4) is a chiral building block with a molecular weight of 211.10 g/mol. This trifluoroacetylated derivative of aspartic acid is valuable in asymmetric synthesis. It serves as a key intermediate in the preparation of pharmaceutical compounds, including dopamine agonists and sweetening agents.

IUPAC: (S)-(−)-2-Trifluoroacetamidosuccinic anhydride,N-Trifluoroacetyl-L-aspartic acid anhydride
Synonyms: (S)-(−)-2-Trifluoroacetamidosuccinic anhydrideN-Trifluoroacetyl-L-aspartic acid anhydride

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(S)-(−)-2-(Trifluoroacetamido)succinic anhydride (C6H4F3NO4) — chemical structure, CAS 777-33-3; Chemistry, fine chemical supplied by Tech Serve Solutions

Asymmetric SynthesisCarboxylic Acid AnhydridesChemical SynthesisChiral Building BlocksOrganic Building Blocks

01 /Applications

Synthesis of Dopamine Agonists

This anhydride is a crucial precursor in the synthesis of 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalen, a known potent dopamine agonist.

Preparation of Sweetening Agents

It is employed in the synthesis of novel sweetening agents, specifically N-trifluoroacetyl-L-aspartic acid α-amides and α-anilides.

Chiral Building Block

Its defined stereochemistry makes it an important chiral building block for the construction of enantiomerically pure complex molecules in organic synthesis.

02 /Properties

Molecular weight	211.10
Empirical formula	C6H4F3NO4
Assay	97%
Optical activity	[α]20/D −28.0°, c = 1 in THF
Application	Useful in the synthesis of 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene, a potent dopamine agonist.1 Used in the synthesis of sweetening agents, such as N-trifluoroacetyl-L-aspartic acid α-amides and α-anilides.2
Melting point	131-132 °C(lit.)

03 /Safety & handling

GHS hazard pictogram: Toxic (GHS06) — Toxic

Danger

Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash thoroughly after handling
P301IF SWALLOWED

Protective equipment	Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Transport (UN / ADR)	UN 2811 6.1 / PGIII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	T
Risk statements (R)	25
Safety statements (S)	36-45

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

777-33-3

MDL number

MFCD00012332

PubChem substance

24858416

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is (S)-(−)-2-(Trifluoroacetamido)succinic anhydride used for?

(S)-(−)-2-(Trifluoroacetamido)succinic anhydride is used in the synthesis of dopamine agonists and sweetening agents, and as a chiral building block in organic synthesis.

What are the CAS number and chemical formula for (S)-(−)-2-(Trifluoroacetamido)succinic anhydride?

The CAS number is 777-33-3 and the chemical formula is C6H4F3NO4.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies this compound at a minimum purity of 97%. We do not represent it as USP, BP, or EP grade.

How should (S)-(−)-2-(Trifluoroacetamido)succinic anhydride be handled?

This compound is classified as acutely toxic if swallowed (H300). Handle with extreme caution, using appropriate personal protective equipment including eyeshields, faceshields, gloves, and P2 respirator cartridges. Ensure adequate ventilation and follow all safety precautions.