(S)-2-Chloro-3-methylbutyric acid
(S)-2-Chloro-3-methylbutyric acid (CAS: 26782-74-1), a chiral carboxylic acid with the formula C5H9ClO2 and a molecular weight of 136.58 g/mol, serves as a valuable building block in organic synthesis. Its defined stereochemistry makes it particularly useful in asymmetric synthesis and for the creation of complex chiral molecules. Available from Tech Serve Solutions, it is supplied with an assay of ≥90% (GC), suitable for research and development applications.
- IUPAC
- (S)-α-Chloroisovaleric acid

Chiral Building Block in Organic Synthesis
Utilised as a key intermediate in the synthesis of more complex chiral molecules. Its stereogenic centre allows for the introduction of specific chirality into target compounds.
Asymmetric Synthesis
A crucial component in stereoselective reactions, enabling chemists to control the formation of specific enantiomers or diastereomers.
Pharmaceutical Intermediate Development
Serves as a precursor in the multi-step synthesis pathways for various active pharmaceutical ingredients (APIs) where specific stereochemistry is critical for efficacy.
Research and Development
Employed in academic and industrial research laboratories for the exploration of novel synthetic routes and the development of new chemical entities.
| Molecular weight | 136.58 |
|---|---|
| Empirical formula | C5H9ClO2 |
| Assay | ≥90% (GC) |
| Density | 1.144 g/mL at 20 °C(lit.) |
| Refractive index | n20/D 1.443 |
| Optical activity | [α]20/D −1.0±0.5°, neat |
| Storage temperature | 2-8°C |

Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Transport (UN / ADR) | UN 3265 8 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (S)-2-Chloro-3-methylbutyric acid primarily used for?
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(S)-2-Chloro-3-methylbutyric acid is primarily used as a chiral building block in asymmetric synthesis and for the development of pharmaceutical intermediates.
What is the CAS number and molecular formula for (S)-2-Chloro-3-methylbutyric acid?
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The CAS number is 26782-74-1 and the molecular formula is C5H9ClO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (S)-2-Chloro-3-methylbutyric acid with a minimum assay of 90% (GC). This product is intended for research and development use and is not supplied as USP, BP, EP, or any other pharmacopoeia grade.
How should (S)-2-Chloro-3-methylbutyric acid be handled safely?
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Due to its corrosive nature (H314), (S)-2-Chloro-3-methylbutyric acid requires careful handling. Always wear appropriate personal protective equipment, including face shields, goggles, and chemical-resistant gloves. Ensure adequate ventilation and have emergency procedures in place.
Is (S)-2-Chloro-3-methylbutyric acid available for export?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including (S)-2-Chloro-3-methylbutyric acid, adhering to all international shipping regulations.
How can I request a quote or sample for (S)-2-Chloro-3-methylbutyric acid?
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To request a quote or sample, please visit the Tech Serve Solutions website or contact our sales team directly with your specific requirements.
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