(S)-2-(Azidomethyl)-1-Boc-pyrrolidine
(S)-2-(Azidomethyl)-1-Boc-pyrrolidine (CAS: 168049-26-1; Formula: C10H18N4O2; MW: 226.28) is a chiral organic building block. This Boc-protected pyrrolidine derivative features an azidomethyl group, making it a versatile intermediate for introducing nitrogen-containing functionalities into complex molecules. It is primarily utilised in asymmetric synthesis and the construction of heterocyclic compounds, finding applications in pharmaceutical research and fine chemical manufacturing.
- IUPAC
- (S)-2-(Azidomethyl)-1-(tert-butoxycarbonyl)pyrrolidine,tert-Butyl (S)-2-(azidomethyl)-1-pyrrolidinecarboxylate
- Synonyms
- tert-Butyl (S)-2-(azidomethyl)-1-pyrrolidinecarboxylate
Chiral Building Block in Organic Synthesis
Serves as a crucial chiral intermediate for constructing enantiomerically pure target molecules, particularly in pharmaceutical and agrochemical research. The pyrrolidine scaffold and azido group offer distinct reaction pathways.
Azide Chemistry and Click Chemistry
The azidomethyl group is amenable to various transformations, including reduction to amines or participation in cycloaddition reactions like the copper-catalysed azide-alkyne cycloaddition (CuAAC), enabling the synthesis of triazole-containing compounds.
Heterocyclic Compound Synthesis
Enables the synthesis of diverse nitrogen-containing heterocycles, such as substituted pyrrolidines and related ring systems, which are prevalent motifs in many bioactive molecules.
Pharmaceutical Intermediate
Acts as a valuable intermediate in the multi-step synthesis of active pharmaceutical ingredients (APIs) and drug candidates, facilitating the introduction of specific stereochemistry and functional groups.
| Molecular weight | 226.28 |
|---|---|
| Empirical formula | C10H18N4O2 |
| Assay | ≥95% (HPLC) |
| Optical activity | [α]/D -48.5±1°, c = 1% in chloroform |
| Optical purity | enantiomeric excess: ≥98% (HPLC) |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (S)-2-(Azidomethyl)-1-Boc-pyrrolidine used for?
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This compound is primarily used as a chiral building block in asymmetric synthesis, for the preparation of heterocyclic compounds, and as an intermediate in pharmaceutical and fine chemical research, particularly via azide chemistry.
What are the CAS number and chemical formula?
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The CAS number is 168049-26-1 and the empirical formula is C10H18N4O2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical with an assay of ≥95% (HPLC) and an enantiomeric excess of ≥98% (HPLC). We do not represent this product as USP, BP, or EP grade.
What are the safety and handling precautions for this chemical?
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This compound requires appropriate personal protective equipment, including eyeshields and gloves. Ensure adequate ventilation and use a type N95 (US) or type P1 (EN143) respirator filter if necessary. It is classified with WGK Germany 3.
How is this chemical shipped and exported?
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Tech Serve Solutions, established in 1998, is a specialist global supplier and exporter of fine chemicals, including (S)-2-(Azidomethyl)-1-Boc-pyrrolidine. We handle all necessary export documentation and comply with international shipping regulations.
How can I request a sample or quote for this chemical?
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Please contact our sales department via the website or by phone to request a sample or a formal quotation for (S)-2-(Azidomethyl)-1-Boc-pyrrolidine.
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