Purvalanol A
Purvalanol A (CAS 212844-53-6), with the molecular formula C19H25ClN6O and a molecular weight of 388.89 g/mol, is a potent and selective inhibitor of Cyclin-Dependent Kinases (CDKs). This bioactive small molecule plays a crucial role in cell cycle regulation. Available as a powder, it is primarily used in research settings to investigate cell proliferation, apoptosis, and related cellular signalling pathways.
- IUPAC
- 2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine,NG-60
Cell Cycle Research
Purvalanol A acts as a specific inhibitor of CDK1, CDK2, CDK5, and CDK9, making it an invaluable tool for studying cell cycle progression and its regulation in various biological models.
Apoptosis Studies
By inhibiting key CDKs involved in cell cycle control, Purvalanol A can induce apoptosis, facilitating research into programmed cell death mechanisms and potential therapeutic interventions.
Kinase Inhibition Studies
As a selective inhibitor, Purvalanol A is utilized in biochemical assays to probe the activity and function of serine/threonine kinases, particularly CDKs, within cellular signalling pathways.
| Molecular weight | 388.89 |
|---|---|
| Empirical formula | C19H25ClN6O |
| Assay | ≥98% (HPLC) |
| Form | powder |
| Solubility | methylene chloride: soluble50 mg/mL |
| Storage temperature | −20°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Shipped In | dry ice |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Purvalanol A used for?
+
Purvalanol A is primarily used in research for investigating cell cycle regulation, apoptosis, and as a selective inhibitor of Cyclin-Dependent Kinases (CDKs), such as CDK1, CDK2, CDK5, and CDK9.
What are the CAS number and formula for Purvalanol A?
+
The CAS number for Purvalanol A is 212844-53-6, and its empirical formula is C19H25ClN6O.
What grade and purity does Tech Serve Solutions supply for Purvalanol A?
+
Tech Serve Solutions supplies Purvalanol A with a purity of ≥98% by HPLC. We do not represent this product as USP, BP, or EP grade.
How is Purvalanol A shipped and stored?
+
Purvalanol A is shipped on dry ice and should be stored at -20°C to maintain its stability and efficacy.
What are the safety precautions when handling Purvalanol A?
+
When handling Purvalanol A, it is essential to use personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is also recommended. It is classified with WGK Germany 3.
How can I request a quote or sample of Purvalanol A?
+
Please contact our sales team or visit our website to request a quote or a sample of Purvalanol A.
▶ Related products
(−)-Curcumol
C15H24O2
Cell Biology
(±) Clopidogrel hydrogensulfate
Cell Biology
(±)-L-Alliin
C6H11NO3S
Cell Biology
(±)-2-Amino-4-phosphonobutyric acid
C4H10NO5P
Cell Biology
(±)-2-Methylarachidonoyl-2′-fluoroethylamide
C23H38NOF
Cell Biology
(±)-3,4-Methylenedioxy-N-ethylamphetamine hydrochloride
Cell Biology
(±)-3,4-Methylenedioxyamphetamine hydrochloride
Cell Biology
(±)-3,4-Methylenedioxymethamphetamine hydrochloride
Cell Biology
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis