Propylphosphonic anhydride solution
Propylphosphonic anhydride solution (CAS 68957-94-8), with the molecular formula C9H21O6P3 and a molecular weight of 318.18 g/mol, is a crucial reagent in organic synthesis. Commonly supplied as approximately 50% in DMF, it acts as a dehydrating and coupling agent. Its applications span the formation of esters, amides, and peptides, making it invaluable in the synthesis of complex organic molecules within the pharmaceutical and chemical industries.
- IUPAC
- 1-Propanephosphonic anhydride solution,2,4,6-Tripropyl-1,3,5,2,4,6-trioxatriphosphorinane-2,4,6-trioxide solution,PPACA,T3P®
Amide and Ester Formation
This anhydride solution serves as an efficient coupling reagent for the synthesis of amides and esters. It facilitates the condensation reaction between carboxylic acids and amines or alcohols, respectively, under mild conditions.
Peptide Synthesis
In peptide synthesis, propylphosphonic anhydride solution is employed to activate carboxylic acid groups, enabling the formation of peptide bonds between amino acids. This is critical for building complex peptide chains.
Dehydrating Agent
As a potent dehydrating agent, it can be utilized in reactions where the removal of water is essential for driving the equilibrium towards product formation. This includes cyclisation reactions and formation of anhydrides.
| Molecular weight | 318.18 |
|---|---|
| Empirical formula | C9H21O6P3 |
| Concentration | ~50% in DMF |
Hazard statements
- H314Causes severe skin burns and eye damage
- H360D
Precautionary statements
- P201Obtain special instructions before use
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 62 °C / 143.6 °F |
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 1 |
| Hazard codes (EU) | T |
| Risk statements (R) | 61-20/21-34 |
| Safety statements (S) | 53-26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Propylphosphonic anhydride solution used for?
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Propylphosphonic anhydride solution (CAS 68957-94-8) is primarily used as a coupling and dehydrating agent in organic synthesis, particularly for the formation of amides, esters, and in peptide synthesis.
What is the CAS number and molecular formula for Propylphosphonic anhydride solution?
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The CAS number is 68957-94-8, and the molecular formula is C9H21O6P3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions typically supplies Propylphosphonic anhydride solution at approximately 50% concentration in DMF. We do not represent this product as USP, BP, or EP grade. Please refer to the product specifications for detailed purity information.
How should Propylphosphonic anhydride solution be handled safely?
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This product is classified as dangerous, with hazards including severe skin burns and eye damage (H314) and potential damage to fertility or the unborn child (H360D). Handle with extreme caution, using full protective equipment including face shields, gloves, and appropriate respiratory protection. Ensure adequate ventilation. Refer to the Safety Data Sheet for comprehensive handling instructions.
Is Propylphosphonic anhydride solution shipped internationally?
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Yes, Tech Serve Solutions is a global supplier and exporter and can ship Propylphosphonic anhydride solution internationally. Please contact us for specific export and shipping details to your region.
How can I request a quote or sample?
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To request a quote or a sample of Propylphosphonic anhydride solution, please contact our sales team through the website or by calling our main office. Provide your specific requirements, including quantity and delivery location.
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