Potassium P,P-dimethylphosphonoacetate
Potassium P,P-dimethylphosphonoacetate (CAS 34170-88-2) is a key organic compound with a molecular weight of 206.18 g/mol. It functions as a valuable reactant in various synthetic procedures, notably in C-C bond formation and olefination reactions. This compound serves as a reagent in the Horner-Wadsworth-Emmons reaction, enabling the synthesis of complex molecules and intermediates for pharmaceutical research and fine chemical production.
- IUPAC
- P,P-Dimethylphosphonoacetic acid potassium salt,Phosphonoacetic acid P,P-dimethyl ester potassium salt
- Synonyms
- (CH3O)2P(O)CH2COOKP,P-Dimethylphosphonoacetic acid potassium saltPhosphonoacetic acid P,P-dimethyl ester potassium salt
Preparation of Michael Acceptor-Containing Oligopeptide-Based Inhibitors
Potassium P,P-dimethylphosphonoacetate acts as a crucial reactant in the synthesis of specialized oligopeptide-based inhibitors. Its incorporation allows for the generation of molecules with specific Michael acceptor functionalities, vital for biochemical studies and drug development.
Condensation Reactions with Chloroacetophenone
This compound participates in condensation reactions, such as those with chloroacetophenone. These reactions are fundamental in organic synthesis for creating new carbon-carbon bonds and forming unsaturated systems, leading to diverse chemical structures.
Horner-Wadsworth-Emmons Reagent
As a reagent within the Horner-Wadsworth-Emmons reaction family, Potassium P,P-dimethylphosphonoacetate facilitates the stereoselective synthesis of alkenes. This method is widely employed in the construction of complex organic molecules, including natural products and pharmaceutical intermediates.
General Chemical Synthesis
Utilised as a versatile building block in general chemical synthesis, it aids in the formation of C-C bonds. Its reactivity profile makes it suitable for a range of transformations, contributing to the development of novel compounds and materials.
| Molecular weight | 206.18 |
|---|---|
| Linear formula | (CH3O)2P(O)CH2COOK |
| Assay | ≥95.0% (NT) |
| Storage temperature | 2-8°C |
| Application | Reactant for:• Preparation of Michael acceptor-containing oligopeptide-based inhibitors1• Condensation reactions with chloroacetophenone2 |
| Melting point | 113-115 °C |
Hazard statements
- H315Causes skin irritation
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 38 |
| Safety statements (S) | 28 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Potassium P,P-dimethylphosphonoacetate used for?
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Potassium P,P-dimethylphosphonoacetate is used as a reactant in the preparation of Michael acceptor-containing oligopeptide-based inhibitors and in condensation reactions with chloroacetophenone. It also serves as a Horner-Wadsworth-Emmons reagent for C-C bond formation and olefination in chemical synthesis.
What is the CAS number and formula for Potassium P,P-dimethylphosphonoacetate?
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The CAS number is 34170-88-2. The linear formula is (CH3O)2P(O)CH2COOK.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Potassium P,P-dimethylphosphonoacetate with an assay of ≥95.0% (NT). This is a technical/research grade material, and TSS does not represent it as USP/BP/EP or for any other specific pharmacopoeia or food-grade application.
How should Potassium P,P-dimethylphosphonoacetate be handled?
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Potassium P,P-dimethylphosphonoacetate is classified as a Warning substance with H315 hazard statement (causes skin irritation). Recommended personal protective equipment includes a dust mask type N95 (US), eyeshields, and gloves. Handle in a well-ventilated area and avoid contact with skin and eyes.
How is Potassium P,P-dimethylphosphonoacetate packaged and shipped?
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Tech Serve Solutions offers Potassium P,P-dimethylphosphonoacetate, which is carefully packaged to ensure stability and integrity during transport. We are a specialist global supplier and exporter, adhering to all regulations for international chemical shipments.
How can I request a quote or sample?
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To request a quote or a sample of Potassium P,P-dimethylphosphonoacetate, please contact our sales team through the website or by phone. Provide the product name and CAS number (34170-88-2) for prompt service.
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