Potassium 2-fluoro-5-formylphenyltrifluoroborate
Potassium 2-fluoro-5-formylphenyltrifluoroborate (CAS: 1012868-70-0, Formula: C7H4BF4KO, MW: 230.01) is a versatile organotrifluoroborate compound used in organic synthesis. It serves as a stable surrogate for boronic acids, participating in various cross-coupling reactions and transformations such as metal-free chlorodeboronation and hydrolysis. This building block is valuable for constructing complex organic molecules, particularly in pharmaceutical and agrochemical research and development.
Suzuki-Miyaura Reactions
Potassium 2-fluoro-5-formylphenyltrifluoroborate can participate in Suzuki-Miyaura cross-coupling reactions, enabling the formation of carbon-carbon bonds. These reactions are fundamental in the synthesis of biaryl compounds and other complex organic structures.
Metal-Free Chlorodeboronation
This compound is employed in metal-free chlorodeboronation reactions, offering an alternative pathway for introducing chlorine atoms into organic molecules. This methodology avoids the use of transition metal catalysts, simplifying reaction work-ups and reducing waste.
Hydrolysis Reactions
Potassium 2-fluoro-5-formylphenyltrifluoroborate can undergo hydrolysis, typically facilitated by silica gel and water. This transformation allows for the conversion of the trifluoroborate moiety into other functional groups, expanding its synthetic utility.
Reductive Amination
The aldehyde functionality within the molecule makes it suitable for reductive amination reactions. This process is crucial for synthesizing amines, which are prevalent in pharmaceuticals and agrochemicals.
| Molecular weight | 230.01 |
|---|---|
| Empirical formula | C7H4BF4KO |
| Application | Organotrifluoroborate involved in:• Metal-free chlorodeboronation1• Hydrolysis via silica gel and water2• Suzuki-Miyaura reactions3• Reductive amination4• Wittig reactions5Organotrifluoroborates as versatile and stable boronic acid surrogates. |
| Melting point | 230-235 °C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What are the primary uses of Potassium 2-fluoro-5-formylphenyltrifluoroborate?
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Potassium 2-fluoro-5-formylphenyltrifluoroborate is primarily used as a versatile building block in organic synthesis. Its applications include participation in Suzuki-Miyaura reactions, metal-free chlorodeboronation, hydrolysis, reductive amination, and Wittig reactions, serving as a stable surrogate for boronic acids.
What is the CAS number and chemical formula for Potassium 2-fluoro-5-formylphenyltrifluoroborate?
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The CAS number is 1012868-70-0, and the chemical formula is C7H4BF4KO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Potassium 2-fluoro-5-formylphenyltrifluoroborate as a research-grade chemical. Purity is typically specified on the Certificate of Analysis; we do not represent this product as USP, BP, EP, or any pharmacopoeia grade.
How should Potassium 2-fluoro-5-formylphenyltrifluoroborate be handled safely?
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This compound is a Warning substance that may cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Always handle in a well-ventilated area, wear appropriate personal protective equipment including gloves, eye protection, and respiratory protection, and avoid breathing dust. Refer to the Safety Data Sheet (SDS) for detailed handling instructions.
How is Potassium 2-fluoro-5-formylphenyltrifluoroborate packed, shipped, and exported?
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This chemical is carefully packed in compliance with international shipping regulations. Tech Serve Solutions is an experienced global exporter of fine chemicals and laboratory reagents.
How can I request a sample or a quote for Potassium 2-fluoro-5-formylphenyltrifluoroborate?
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To request a sample or a quote, please contact our sales department through the website or by phone, providing the product name and CAS number (1012868-70-0).
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