Potassium 1H-pyrazole-3-trifluoroborate
Potassium 1H-pyrazole-3-trifluoroborate (CAS: 1013640-87-3), with the molecular formula C3H3BF3KN2 and a molecular weight of 173.97 g/mol, is a valuable organotrifluoroborate reagent. It serves as a stable surrogate for boronic acids, primarily employed in Suzuki-Miyaura cross-coupling reactions. This compound is a key building block in organic synthesis, facilitating the formation of carbon-carbon bonds in complex molecule construction, particularly within the pharmaceutical and agrochemical industries.
- IUPAC
- Potassium 1H-pyrazole-5-trifluoroborate,Potassium pyrazole-5-trifluoroborate
Suzuki-Miyaura Cross-Coupling Reactions
Potassium 1H-pyrazole-3-trifluoroborate is extensively used as a coupling partner in Palladium-catalysed Suzuki-Miyaura reactions. It enables the efficient synthesis of biaryl compounds and other structures containing a pyrazole moiety, which are prevalent in medicinal chemistry.
Organic Synthesis Building Block
This trifluoroborate salt acts as a versatile synthon for introducing the 1H-pyrazole-3-yl group into organic molecules. Its stability and reactivity profile make it a preferred reagent for various synthetic transformations requiring precise functional group incorporation.
Medicinal Chemistry Intermediate
The pyrazole ring is a common scaffold in pharmaceuticals. Potassium 1H-pyrazole-3-trifluoroborate provides a convenient route to synthesise pyrazole-containing drug candidates and active pharmaceutical ingredients (APIs).
| Molecular weight | 173.97 |
|---|---|
| Empirical formula | C3H3BF3KN2 |
| Application | An Organotrifluoroborate involved in Suzuki-Miyaura cross-coupling reactions1Organotrifluoroborates as versatile and stable boronic acid surrogates. |
| Melting point | 196-200 °C |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
Precautionary statements
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Potassium 1H-pyrazole-3-trifluoroborate used for?
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Potassium 1H-pyrazole-3-trifluoroborate is primarily used as a reagent in Suzuki-Miyaura cross-coupling reactions and as a building block in organic synthesis, particularly for introducing the pyrazole moiety into target molecules.
What is the CAS number and formula for Potassium 1H-pyrazole-3-trifluoroborate?
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The CAS number is 1013640-87-3 and the empirical formula is C3H3BF3KN2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Potassium 1H-pyrazole-3-trifluoroborate with a minimum purity of 97%. This product is supplied for laboratory and research use and is not intended for USP, BP, EP, or other pharmacopoeial applications.
How should Potassium 1H-pyrazole-3-trifluoroborate be handled safely?
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Potassium 1H-pyrazole-3-trifluoroborate is classified as harmful if swallowed and causes skin and eye irritation (H302, H315, H319). Handle with appropriate personal protective equipment, including gloves, eye protection, and avoid inhalation of dust. Ensure good ventilation.
Is this product available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including Potassium 1H-pyrazole-3-trifluoroborate, serving customers worldwide.
How can I request a quote or sample?
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To request a quote or sample of Potassium 1H-pyrazole-3-trifluoroborate, please contact our sales team through the website or by email, providing your contact details and the quantity required.
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