Poly-L-histidine
Poly-L-histidine (CAS: 26062-48-6) is a synthetic homopolymer of the amino acid L-histidine. It is supplied with a molecular weight range of 5,000-25,000 Da. This polyamino acid is a valuable reagent in biochemical research, particularly for studies involving protein interactions, metal chelation, and as a component in biomaterials.

Biochemical Research Reagent
Poly-L-histidine serves as a versatile tool in molecular biology and biochemistry. Its histidine residues offer metal-binding capabilities, making it useful in affinity chromatography and for studying metalloproteins.
Biomaterials Development
The polymer can be incorporated into hydrogels and other biomaterials for drug delivery systems or tissue engineering scaffolds. Its properties can be tailored by controlling molecular weight and its environment.
Protein Interaction Studies
As a model polypeptide, Poly-L-histidine is employed to investigate the principles of protein folding, aggregation, and interactions with other biomolecules or surfaces.
| Storage temperature | −20°C |
|---|
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Mol Wt | mol wt 5,000-25,000 |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Poly-L-histidine used for?
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Poly-L-histidine is primarily used as a reagent in biochemical research for studies involving metal chelation, protein interactions, and as a component in developing biomaterials.
What is the CAS number and formula for Poly-L-histidine?
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The CAS number for Poly-L-histidine is 26062-48-6. The chemical formula for homopolymers is typically represented as (C6H9N3O2)n.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Poly-L-histidine with a molecular weight range of 5,000-25,000 Da. It is supplied as a research-grade chemical, and TSS does not represent it as USP, BP, EP, or pharmacopoeia grade.
How should Poly-L-histidine be handled safely?
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Handling Poly-L-histidine requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. Consult the Safety Data Sheet (SDS) for full details.
How is Poly-L-histidine shipped and exported?
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Poly-L-histidine is typically stored at -20°C. TSS adheres to all regulations for the safe packaging, handling, and international export of fine chemicals.
How can I request a sample or quote for Poly-L-histidine?
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To request a sample or a quote for Poly-L-histidine, please contact our sales team through the website or by phone, providing the product name and CAS number.
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