Poly(2-ethyl-2-oxazoline)
Poly(2-ethyl-2-oxazoline) (CAS: 25805-17-8), with the linear formula [-N(COC2H5)CH2CH2-]n, is an amorphous, water-soluble polymer exhibiting good temperature stability. Its biocompatibility, lack of tissue accumulation, and rapid blood clearance have been documented. This polymer is a versatile alternative to polyethylene glycol (PEG) for conjugating peptides, proteins, and small drugs, finding use as an adhesion promoter and a component in hot-melt adhesives.
- IUPAC
- PEOX,POx,PetOx,poly 2-ethyloxazoline,polyethyloxazoline
- Synonyms
- Poly(2-ethyl-2-oxazoline)
![Poly(2-ethyl-2-oxazoline) ([-N(COC2H5)CH2CH2-]n) — chemical structure, CAS 25805-17-8; Materials Science, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F25805-17-8.png&w=3840&q=75)
Biocompatible Conjugation Agent
Demonstrated biocompatibility, no tissue accumulation, and rapid clearance make it an ideal alternative to PEG for conjugating peptides, proteins, and drugs.
Adhesion Promoter
Serves as an effective adhesion promoter in various coating applications.
Adhesive Formulations
Utilised in heat sealing and remoistenable hot-melt adhesive formulations.
Polymer Science Research
A valuable material in polymer science for developing novel materials and investigating polymer properties.
| Linear formula | [-N(COC2H5)CH2CH2-]n |
|---|---|
| Density | 1.14 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.52 |
| Application | This Poly(2-ethyl-2-oxazoline) polymer is amorphous and water soluble with good temperature stability. Jordan and coworkers showed biocompatibility, no accumulation in tissue, and rapid clearance from the bloodstream1. End-group modified poly(2-ethyl-2-oxazoline)s have been conjugated to peptides2, and were shown as versatile alternatives to poly(ethylene glycol) (PEG) for both protein and small drug conjugation3.Potential substitute for poly(vinyl alcohol) and poly(vinyl pyrrolidone). Adhesion promoter in coatings. Heat sealing and remoistenable hot-melt adhesive |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Mol Wt | average Mw ~50,000 |
|---|---|
| Transition Temp | softening point 110-120 °C (Vicat, ASTM D 1525-82)Tg 69-71 °C |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Poly(2-ethyl-2-oxazoline) used for?
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Poly(2-ethyl-2-oxazoline) is used as a biocompatible conjugation agent for peptides, proteins, and drugs, as an adhesion promoter in coatings, and in heat sealing and remoistenable hot-melt adhesives. It is also a material of interest in polymer science research.
What are the CAS number and chemical formula for Poly(2-ethyl-2-oxazoline)?
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The CAS number for Poly(2-ethyl-2-oxazoline) is 25805-17-8, and its linear formula is [-N(COC2H5)CH2CH2-]n.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Poly(2-ethyl-2-oxazoline) with an average molecular weight (Mw) of approximately 50,000. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade. For specific purity requirements, please contact our sales team.
What are the safety and handling guidelines for Poly(2-ethyl-2-oxazoline)?
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When handling Poly(2-ethyl-2-oxazoline), it is recommended to use safety measures including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is advised. The product has a WGK Germany classification of 3, indicating a higher hazard to water.
How is Poly(2-ethyl-2-oxazoline) packed, shipped, and exported?
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Poly(2-ethyl-2-oxazoline) is carefully packed to ensure product integrity during transit. Tech Serve Solutions, as a specialist global supplier, exports fine chemicals, pharmaceutical intermediates, and laboratory reagents worldwide.
How can I request a sample or quote for Poly(2-ethyl-2-oxazoline)?
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To request a sample or a quotation for Poly(2-ethyl-2-oxazoline), please contact our customer service department via the website or direct email.
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