Piperidine hydrochloride
Piperidine hydrochloride (CAS 6091-44-7, C5H11N · HCl) is a white crystalline solid with a molecular weight of 121.61 g/mol. This chemical serves as a valuable reagent and reactant in various organic syntheses. Its applications include the preparation of quinoline selenium compounds, peripheral serotonin 5-HT3 receptor ligands, and phthalazinone derivatives with potential phosphodiesterase 4 inhibitory activity. It is also employed in Mannich reactions and asymmetric hydrogenation.
Synthesis of Quinoline Selenium Compounds
Piperidine hydrochloride acts as a reagent in the synthesis of specialized quinoline selenium compounds, contributing to the development of novel chemical entities.
Development of Serotonin Receptor Ligands
It is utilized in the creation of peripheral serotonin 5-HT3 receptor ligands, important in pharmaceutical research and drug discovery for neurological targets.
Preparation of Phosphodiesterase 4 Inhibitors
Piperidine hydrochloride is a reactant in synthesising phthalazinone derivatives investigated as topically active phosphodiesterase 4 inhibitors.
Mannich Reactions and Reductive Amination
This compound participates in Mannich reactions and chemoselective reductive amination of carbonyl compounds, showcasing its utility in fundamental organic transformations.
Asymmetric Hydrogenation
It serves as a reactant in the asymmetric hydrogenation of quinolines, a key process for producing chiral molecules in synthetic chemistry.
| Molecular weight | 121.61 |
|---|---|
| Empirical formula | C5H11N · HCl |
| Assay | 99% |
| Vapour pressure | 63.6 mmHg (37.8 °C) |
| Vapour density | 2.94 (vs air) |
| Application | Reagent for synthesis of:• Quinoline selenium compounds1• Peripheral seratonin 5-HT3 receptor ligands2Reactant for synthesis of phthalazinone derivatives as topically active phosphodiesterase 4 inhibitors3Reactant for:• Mannich reactions4• Asymmetric hydrogenation of quinolines5• Chemoselective reductive amination of carbonyl compounds6 |
| Melting point | 245-248 °C(lit.) |
Hazard statements
- H301Toxic if swallowed
Precautionary statements
- P301IF SWALLOWED
| Protective equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 25-37 |
| Safety statements (S) | 36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Piperidine hydrochloride used for?
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Piperidine hydrochloride is used as a reagent and reactant in various organic syntheses, including the preparation of quinoline selenium compounds, peripheral serotonin 5-HT3 receptor ligands, and phthalazinone derivatives. It also features in Mannich reactions, asymmetric hydrogenation of quinolines, and chemoselective reductive amination of carbonyl compounds.
What are the CAS number and formula for Piperidine hydrochloride?
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The CAS number for Piperidine hydrochloride is 6091-44-7 and its formula is C5H11N · HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Piperidine hydrochloride with an assay of 99%. This product is typically supplied for research and chemical synthesis purposes and is not represented as USP, BP, EP, or any other pharmacopoeia grade.
How should Piperidine hydrochloride be handled safely?
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Piperidine hydrochloride is classified as 'Danger' (GHS06) with hazard statement H301 (Toxic if swallowed). Handle with appropriate personal protective equipment including eyeshields, faceshields, gloves, and a P2 respirator. Follow precautionary statements P301 + P310 (If swallowed: Immediately call a poison center or doctor).
Is Piperidine hydrochloride a controlled substance?
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The provided data does not indicate that Piperidine hydrochloride (CAS 6091-44-7) is a controlled substance.
How is Piperidine hydrochloride packed and exported?
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Piperidine hydrochloride is packed according to industry standards for chemical reagents and can be exported globally by Tech Serve Solutions, adhering to all relevant shipping regulations, including UN 2811, 6.1/PGIII classification.
How can I request a sample or quote for Piperidine hydrochloride?
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To request a sample or obtain a quote for Piperidine hydrochloride, please contact Tech Serve Solutions directly through our website or designated sales channels.
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