Phosphoramidon disodium salt
Phosphoramidon disodium salt (CAS: 119942-99-3; C23H32N3Na2O10P; MW: 587.47) is a bioactive small molecule and biochemical reagent. It acts as a potent inhibitor of metalloproteinases, including endothelin converting enzyme. This compound is valuable in research for characterising proteolytic enzymes and investigating their roles in biological processes, such as amyloid precursor processing in Alzheimer's disease research. It is supplied with an assay of ≥97% (TLC).
- IUPAC
- N-(α-Rhamnopyranosyloxyhydroxyphosphinyl)-Leu-Trp disodium salt,N-(α-Rhamnopyranosylphosphono)-L-leucyl-L-tryptophan disodium salt
Metallo-endopeptidase Inhibition
Phosphoramidon disodium salt is utilized as a selective inhibitor of metallo-endopeptidases, such as endothelin converting enzyme (ECE). Its application aids in the biochemical characterisation of these enzymes and their specific roles in biological pathways.
Alzheimer's Disease Research
Research indicates that phosphoramidon can increase the production of beta-amyloid protein. This suggests its use in studying the involvement of metallo-endopeptidases in the abnormal processing of amyloid precursors relevant to Alzheimer's disease.
Biochemical Research Tool
As a broad-spectrum inhibitor of proteolytic enzyme classes, phosphoramidon disodium salt serves as a valuable tool in molecular biology and cell biology research. It facilitates the study of protein degradation and processing pathways.
| Molecular weight | 587.47 |
|---|---|
| Empirical formula | C23H32N3Na2O10P |
| Assay | ≥97% (TLC) |
| Solubility | H2O: soluble1 mM (Stock solution stable for 1 month at –20° C.)DMSO: solublemethanol: soluble |
| Storage temperature | −20°C |
| Application | Identification of phosphoramidon as a metallo-endopeptidase inhibitor was used to characterize endothelin converting enzyme as a metallo-endopeptidase.1 Phosphoramidon increases the production of β-amyloid protein, but not amyloid precursor protein, indicating that abnormal amyloid processing in Alzheimer′s disease may be carried out by a metallo-endopeptidase.2 |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Phosphoramidon disodium salt used for?
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Phosphoramidon disodium salt is used as a biochemical reagent and a metalloproteinase inhibitor in research. It aids in characterizing enzymes like endothelin converting enzyme and investigating its role in processes such as beta-amyloid protein production, relevant to diseases like Alzheimer's.
What are the CAS number and formula for Phosphoramidon disodium salt?
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The CAS number for Phosphoramidon disodium salt is 119942-99-3, and its empirical formula is C23H32N3Na2O10P.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Phosphoramidon disodium salt with a purity of ≥97% (TLC). This product is intended for research purposes and is not supplied as USP, BP, or EP grade.
How should Phosphoramidon disodium salt be handled safely?
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When handling Phosphoramidon disodium salt, it is essential to use appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is also recommended. The substance has a WGK Germany rating of 3, indicating a high hazard to water.
How is Phosphoramidon disodium salt shipped and exported?
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Phosphoramidon disodium salt is shipped and exported by Tech Serve Solutions under appropriate conditions for chemical transport. Please contact us for specific details regarding international shipping and export regulations.
How can I request a quote or sample of Phosphoramidon disodium salt?
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To request a quote or a sample of Phosphoramidon disodium salt, please contact our sales department through the website or by phone. Our team will be happy to assist you with your inquiry.
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