Phenylacetyl chloride
Phenylacetyl chloride (CAS 103-80-0), with the molecular formula C8H7ClO and a molar mass of 154.59 g/mol, is a reactive acid halide. It is a key intermediate in organic synthesis, primarily utilised for introducing the phenylacetyl group into various organic molecules. This compound serves as a valuable building block in the preparation of pharmaceuticals and other fine chemicals, demanding careful handling due to its corrosive and irritant properties.
Organic Synthesis Intermediate
Phenylacetyl chloride acts as an essential acylating agent in organic chemistry. It readily reacts with nucleophiles such as alcohols and amines to form esters and amides, respectively, facilitating the construction of more complex molecular structures.
Pharmaceutical Precursor
This compound is instrumental in the synthesis of various pharmaceutical compounds. Its ability to introduce the phenylacetyl moiety makes it a critical starting material or intermediate in the multi-step production of active pharmaceutical ingredients (APIs).
Reagent in Chemical Manufacturing
Utilised in the fine chemical industry, phenylacetyl chloride serves as a versatile reagent for chemical manufacturers. It enables the precise introduction of specific functional groups required in the production of specialised chemicals and materials.
| Molecular weight | 154.59 |
|---|---|
| Linear formula | C6H5CH2COCl |
| Assay | ≥98.0% (AT) |
| Boiling point | 94-95 °C/12 mmHg(lit.) |
| Density | 1.167 g/mL at 20 °C1.169 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.5325(lit.)n20/D 1.533 |
Hazard statements
- H314Causes severe skin burns and eye damage
- H335May cause respiratory irritation
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 102 °C / 215.6 °F |
| Transport (UN / ADR) | UN 2577 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34-37 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Phenylacetyl chloride primarily used for?
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Phenylacetyl chloride is primarily used as an intermediate in organic synthesis, particularly in the preparation of pharmaceuticals and fine chemicals, by introducing the phenylacetyl group into other molecules.
What are the CAS number and chemical formula for Phenylacetyl chloride?
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The CAS number for Phenylacetyl chloride is 103-80-0, and its chemical formula is C8H7ClO.
What grade and purity does Tech Serve Solutions supply for Phenylacetyl chloride?
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Tech Serve Solutions supplies Phenylacetyl chloride with an assay of ≥98.0% (AT). We do not represent this product as USP, BP, or EP grade; it is supplied for technical and research purposes.
What are the main safety hazards associated with Phenylacetyl chloride?
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Phenylacetyl chloride is corrosive and can cause severe skin burns and eye damage (H314). It may also cause respiratory irritation (H335). Appropriate personal protective equipment, including gloves, goggles, and respiratory protection, is essential during handling.
Is Phenylacetyl chloride a controlled substance?
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Information regarding controlled substance status is not provided in the product data. Customers should consult local regulations.
How is Phenylacetyl chloride packed, shipped, and exported?
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Phenylacetyl chloride is shipped as UN 2577, Class 8, Packing Group II, according to ADR regulations. Specific packing details are available upon request.
How can I request a sample or a quote for Phenylacetyl chloride?
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To request a sample or a quote for Phenylacetyl chloride, please contact our sales department through the website or by phone.
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