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Pentadecafluorooctanoyl chloride

CAS 335-64-8CF3(CF2)6COClChemical Synthesis

Pentadecafluorooctanoyl chloride (CAS: 335-64-8), with the linear formula CF<sub>3</sub>(CF<sub>2</sub>)<sub>6</sub>COCl and a molecular weight of 432.51 g/mol, is a specialised fluorinated acyl chloride. It is a key intermediate for introducing the perfluorooctanoyl group into various molecules. This compound is primarily utilised in chemical synthesis, particularly within fluorous synthesis and in the development of Rf-tagged building blocks and precursors for advanced materials.

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Pentadecafluorooctanoyl chloride (CF3(CF2)6COCl) — chemical structure, CAS 335-64-8; Chemistry, fine chemical supplied by Tech Serve Solutions
Chemical SynthesisFluorous SynthesisSpecialty Synthesis
01 /Applications

Fluorous Synthesis Reagent

Pentadecafluorooctanoyl chloride serves as a valuable reagent in fluorous synthesis. It enables the incorporation of perfluorinated chains, which can later be leveraged for selective separation and purification techniques based on fluorous phase compatibility.

Building Block for Specialty Polymers

This compound can be used to synthesise monomers or modify existing polymers, imparting unique properties such as hydrophobicity, oleophobicity, and chemical resistance due to the highly fluorinated octanoyl moiety.

Intermediate in Organic Synthesis

As an acyl chloride, it readily reacts with nucleophiles like alcohols and amines to form esters and amides, respectively. This reactivity makes it a versatile intermediate for creating complex fluorinated organic molecules.

Precursor for Rf-Tagged Compounds

It is employed in the synthesis of Rf-tagged compounds, which are useful in areas like combinatorial chemistry and drug discovery for facilitating purification and screening processes.

02 /Properties
Molecular weight432.51
Linear formulaCF3(CF2)6COCl
Assay97%
Boiling point129-130 °C/744 mmHg(lit.)
Density1.744 g/mL at 25 °C(lit.)
Refractive indexn20/D 1.3045(lit.)
03 /Safety & handling
GHS hazard pictogram: Corrosive (GHS05)
Corrosive
Danger

Hazard statements

  • H314Causes severe skin burns and eye damage

Precautionary statements

  • P280Wear protective gloves, clothing and eye/face protection
  • P305IF IN EYES
  • P310Immediately call a POISON CENTER or doctor
Protective equipmentFaceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Flash point113 °C / 235.4 °F
Transport (UN / ADR)UN 3265 8 / PGII
Water hazard class (WGK, DE)3
Hazard codes (EU)C
Risk statements (R)34
Safety statements (S)26-36/37/39-45

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry
CAS number
335-64-8
MDL number
MFCD00013654
PubChem substance
24857497
05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Pentadecafluorooctanoyl chloride used for?

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Pentadecafluorooctanoyl chloride is primarily used in chemical synthesis, fluorous synthesis, and as a precursor for Rf-tagged building blocks. It acts as a reagent to introduce the perfluorooctanoyl group into other molecules.

What is the CAS number and formula for Pentadecafluorooctanoyl chloride?

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The CAS number for Pentadecafluorooctanoyl chloride is 335-64-8, and its linear formula is CF<sub>3</sub>(CF<sub>2</sub>)<sub>6</sub>COCl.

What grade and purity does Tech Serve Solutions supply?

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Tech Serve Solutions supplies Pentadecafluorooctanoyl chloride with an assay of 97%. We do not represent this product as meeting USP, BP, or EP pharmacopoeia standards.

How should Pentadecafluorooctanoyl chloride be handled safely?

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Pentadecafluorooctanoyl chloride is a corrosive substance. Handle with extreme care, wearing appropriate personal protective equipment including faceshields, chemical-resistant gloves, goggles, and a suitable respirator. Avoid contact with skin, eyes, and clothing. It causes severe skin burns and eye damage (H314).

Is Pentadecafluorooctanoyl chloride exported by TSS?

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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including Pentadecafluorooctanoyl chloride.

How can I request a sample or quote for Pentadecafluorooctanoyl chloride?

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To request a sample or a quotation, please contact our sales team through the website or by phone, providing your specific requirements.

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