PBDA
PBDA (CAS: 229472-51-9), with the molecular formula C12H19O10P and a molecular weight of 354.25 g/mol, is a biochemical reagent. It serves as a potent inhibitor of glutamate carboxypeptidase II (NAAG peptidase) and a selective agonist for mGluR₃ metabotropic glutamate receptors. This compound is valuable in cellular biology and neuroscience research, particularly for studies involving cell signaling pathways and excitatory amino acid receptor modulation.
- IUPAC
- 4,4′-Phosphinicobis(butane-1,3-dicarboxylic acid)
Glutamate Carboxypeptidase II Inhibition
PBDA acts as a potent inhibitor of glutamate carboxypeptidase II, also known as NAAG peptidase. This activity makes it a useful tool for researchers investigating the role of NAAG in neurological processes and disorders.
mGluR₃ Receptor Agonism
This compound is a selective agonist for the mGluR₃ metabotropic glutamate receptor. Its use allows for targeted studies of glutamatergic neurotransmission and the physiological functions mediated by this specific receptor subtype.
Cell Signaling and Neuroscience Research
PBDA is employed in cell signaling research, particularly within neuroscience. Its ability to modulate excitatory amino acid pathways provides insights into neuronal function, synaptic plasticity, and potential therapeutic targets.
| Molecular weight | 354.25 |
|---|---|
| Empirical formula | C12H19O10P |
| Assay | >95% (NMR) |
| Form | liquid |
| Storage temperature | −20°C |
| Application | Potent inhibitor of glutamate carboxypeptidase II (NAAG peptidase), selective mGluR3-metabotropic glutamate receptor- agonist. |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is PBDA used for?
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PBDA is used as a potent inhibitor of glutamate carboxypeptidase II (NAAG peptidase) and a selective agonist for mGluR₃ metabotropic glutamate receptors. It is valuable in cell biology, cell signaling, and neuroscience research.
What is the CAS number and formula for PBDA?
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The CAS number for PBDA is 229472-51-9, and its empirical formula is C12H19O10P.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies PBDA with an assay of >95% (NMR). This compound is supplied for research and laboratory use, and is not represented as USP, BP, or EP grade.
What are the safety and handling precautions for PBDA?
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PBDA is classified as a danger material (GHS05), causing severe skin burns and eye damage (H314). Appropriate personal protective equipment, including gloves, goggles, and respiratory protection (type ABEK), is essential. Handle with extreme caution in a well-ventilated area.
How is PBDA packed, shipped, and exported?
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PBDA is shipped under UN 3265, Class 8, Packing Group II, indicating it is a corrosive liquid, solid, acidic, organic, n.o.s. (Phosphinicobis(butane-1,3-dicarboxylic acid)). TSS exports chemicals globally, adhering to all relevant shipping regulations.
How can I request a quote or sample for PBDA?
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To request a quote or sample for PBDA, please contact our sales team through the provided channels on the Tech Serve Solutions website.
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