p-Tolylmagnesium bromide solution
p-Tolylmagnesium bromide solution (CAS: 4294-57-9, CH3C6H4MgBr, MW: 195.34) is a versatile Grignard reagent supplied by Tech Serve Solutions. It is a key organometallic compound used extensively in organic synthesis for forming new carbon-carbon bonds. This solution in diethyl ether is primarily utilised in the preparation of complex organic molecules within pharmaceutical and fine chemical research and development.
- IUPAC
- 4-Methylphenylmagnesium bromide
- Synonyms
- 4-Methylphenylmagnesium bromide
Carbon-Carbon Bond Formation
p-Tolylmagnesium bromide is a potent nucleophile used in Grignard reactions to introduce the p-tolyl group onto electrophilic carbon centres, facilitating the synthesis of diverse organic structures.
Synthesis of Pharmaceutical Intermediates
This reagent serves as a crucial building block in multi-step syntheses, enabling the construction of complex molecular frameworks required for active pharmaceutical ingredients (APIs).
Fine Chemical Manufacturing
It is employed in the production of various fine chemicals, where precise control over the introduction of the p-tolyl moiety is essential for achieving target compound specifications.
Organometallic Chemistry Research
As a well-defined organometallic reagent, it is utilised in academic and industrial research laboratories for exploring new synthetic methodologies and catalytic processes.
| Molecular weight | 195.34 |
|---|---|
| Linear formula | CH3C6H4MgBr |
| Concentration | 0.5 M in diethyl ether |
Hazard statements
- H224Extremely flammable liquid and vapour
- H302Harmful if swallowed
- H314Causes severe skin burns and eye damage
- H336May cause drowsiness or dizziness
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | -40 °C / -40 °F |
| Transport (UN / ADR) | UN 2924 8(3) / PGI |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F+,C |
| Risk statements (R) | 12-14-19-22-34-66-67 |
| Safety statements (S) | 16-26-36/37/39-45 |
| Supplemental hazards | May form explosive peroxides., Reacts violently with water., Repeated exposure may cause skin dryness or cracking. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is p-Tolylmagnesium bromide solution used for?
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p-Tolylmagnesium bromide solution is used in organic synthesis for the formation of carbon-carbon bonds, particularly in the preparation of pharmaceutical intermediates and fine chemicals.
What is the CAS number and formula for p-Tolylmagnesium bromide solution?
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The CAS number is 4294-57-9 and the linear formula is CH3C6H4MgBr.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies p-Tolylmagnesium bromide solution at 0.5 M in diethyl ether. We do not claim USP, BP, or EP grade unless explicitly stated; please verify with product specifications for lot-specific details.
What are the primary hazards associated with p-Tolylmagnesium bromide solution?
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This solution is highly flammable (H224) and corrosive (H314). It can cause severe skin burns and eye damage, and may cause drowsiness or dizziness (H336). It may also be harmful if swallowed (H302) and can react violently with water. It may form explosive peroxides.
How is p-Tolylmagnesium bromide solution shipped and exported?
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p-Tolylmagnesium bromide solution is shipped and exported according to international regulations for hazardous materials, typically as UN 2924. Please contact TSS for specific shipping requirements for your region.
How can I request a sample or quote for p-Tolylmagnesium bromide solution?
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To request a sample or quote, please contact our sales team through the website or by phone, providing your specific requirements and delivery details.
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