p-Phenylene diisothiocyanate
p-Phenylene diisothiocyanate (CAS 4044-65-9), with the molecular formula C6H4(NCS)2 and a molecular weight of 192.26, is a valuable reagent in chemical synthesis and biology. It serves as a crosslinker and linker, particularly useful in peptide chemistry and for conjugating biomolecules. Its difunctional nature allows for the formation of stable linkages, making it instrumental in various analytical and synthetic applications.
- IUPAC
- 1,4-Diisothiocyanatobenzene,Bitoscanate,PDITC
Peptide Chemistry
p-Phenylene diisothiocyanate is employed in peptide synthesis and modification. Its ability to react with amino groups allows for crosslinking peptides or attaching them to solid supports and other molecules.
Bioconjugation
This compound acts as a heterobifunctional crosslinker, enabling the covalent attachment of proteins, antibodies, or other biomolecules to surfaces, beads, or other labeling agents for diagnostic or research purposes.
Chemical Synthesis
As a difunctional reagent, it participates in the synthesis of various heterocyclic compounds and polymers. It is a key intermediate for creating more complex organic molecules.
Product Analysis
Used in analytical chemistry, it can facilitate derivatization of analytes containing primary amine groups, enhancing their detectability or separability in chromatographic methods.
| Molecular weight | 192.26 |
|---|---|
| Linear formula | C6H4(NCS)2 |
| Assay | 98% |
| Melting point | 129-131 °C(lit.) |
Hazard statements
- H301Toxic if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H334May cause allergy or asthma symptoms if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P301IF SWALLOWED
- P305IF IN EYES
- P342
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38-42 |
| Safety statements (S) | 22-26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is p-Phenylene diisothiocyanate used for?
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p-Phenylene diisothiocyanate is primarily used in chemical biology and chemical synthesis as a crosslinker and linker, particularly in peptide chemistry and for bioconjugation and product analysis.
What are the CAS number and formula for p-Phenylene diisothiocyanate?
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The CAS number is 4044-65-9, and the molecular formula is C6H4(NCS)2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies p-Phenylene diisothiocyanate with an assay of 98%. This product is intended for research and technical use; TSS does not represent it as USP, BP, EP, or other pharmacopoeia grades.
How should p-Phenylene diisothiocyanate be handled safely?
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Handle with appropriate personal protective equipment including a dust mask type N95, eyeshields, face shield, and gloves. Avoid inhalation of dust and contact with skin and eyes. It is a toxic substance and an irritant.
How is p-Phenylene diisothiocyanate packed and exported?
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p-Phenylene diisothiocyanate is packed according to international regulations for hazardous materials and is exported globally by Tech Serve Solutions.
How can I request a quote or sample for p-Phenylene diisothiocyanate?
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To request a quote or a sample, please contact the Tech Serve Solutions sales team through our website or by phone.
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