O-(2-Oxo-1(2H)pyridyl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate
O-(2-Oxo-1(2H)pyridyl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate (CAS 125700-71-2) is a synthetic reagent with the molecular formula C10H16BF4N3O2 and a molecular weight of 297.06 g/mol. This uronium salt is primarily employed in chemical synthesis, particularly in peptide chemistry, facilitating efficient peptide bond formation. Its structure enables it to act as an activating agent in various organic transformations.
- IUPAC
- O-(1,2-Dihydro-2-oxo-1-pyridyl)-N,N,N′-N′-tetramethyluronium tetrafluoroborate,TPTU
- Synonyms
- O-(1,2-Dihydro-2-oxo-1-pyridyl)-N,N,N′-N′-tetramethyluronium tetrafluoroborate,TPTU,N′-tetramethyluronium tetrafluoroborate

Peptide Synthesis
This compound is a valuable reagent for the formation of peptide bonds, enabling the efficient coupling of amino acids in solid-phase and solution-phase peptide synthesis.
Chemical Synthesis
Utilised as an activating agent in general organic synthesis, it promotes amide bond formation and other coupling reactions critical for the construction of complex molecules.
Chemical Biology
Its role in facilitating coupling reactions makes it useful in chemical biology for the synthesis of peptides and modified biomolecules.
| Molecular weight | 297.06 |
|---|---|
| Empirical formula | C10H16BF4N3O2 |
| Assay | 97% |
| Melting point | 140 °C (dec.)(lit.) |
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is O-(2-Oxo-1(2H)pyridyl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate used for?
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This uronium salt is primarily used as a coupling reagent in peptide synthesis and other chemical synthesis applications requiring amide bond formation.
What is the CAS number and formula for this compound?
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The CAS number is 125700-71-2 and the empirical formula is C10H16BF4N3O2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical with an assay of 97%. We do not represent this product as USP, BP, EP or other pharmacopoeia grades.
What are the safety and handling considerations for this chemical?
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This compound is an irritant (Xi) and may cause respiratory irritation (R37). It is advisable to wear Eyeshields, Gloves, and a dust mask type N95 (US) when handling. Store in a cool, dry place.
How is this chemical packed, shipped, and exported?
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Tech Serve Solutions offers this chemical in various pack sizes suitable for laboratory and industrial use, adhering to all necessary shipping and export regulations for fine chemicals.
How can I request a sample or quote?
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To request a sample or a quotation, please contact our sales team through the website or by phone, providing the product name and CAS number (125700-71-2).
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