Nutlin-3
Nutlin-3 (CAS: 548472-68-0), with the molecular formula C30H30Cl2N4O4 and a molecular weight of 581.49 g/mol, is a research chemical. It is primarily recognised for its role as an apoptosis inducer and its applications in cell biology and signalling research. This compound is supplied as a powder and is a valuable tool for scientific investigation in these fields.
- IUPAC
- (±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one
Apoptosis Research
Nutlin-3 is widely used as a selective inhibitor of the MDM2-p53 interaction, leading to the stabilisation and activation of p53. This mechanism makes it an important tool for studying apoptosis induction in various cellular models.
Cell Cycle and Cancer Studies
By modulating the p53 pathway, Nutlin-3 can induce cell cycle arrest. Researchers utilise this compound to investigate potential therapeutic strategies targeting cancer cells that rely on the MDM2-p53 axis for survival.
Drug Discovery and Development
As a bioactive small molecule and a drug candidate, Nutlin-3 serves as a valuable reference compound or starting point in drug discovery programmes focused on developing novel anti-cancer agents or modulators of cellular stress responses.
| Molecular weight | 581.49 |
|---|---|
| Empirical formula | C30H30Cl2N4O4 |
| Assay | ≥98% (HPLC) |
| Form | powder |
| Solubility | DMSO: soluble20 mg/mLH2O: insoluble |
| Storage temperature | −20°C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Shipped In | wet ice |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Nutlin-3 used for?
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Nutlin-3 is used in scientific research primarily as an apoptosis inducer and a modulator of the MDM2-p53 interaction, making it valuable for studies in cell biology, cell cycle regulation, and cancer research.
What are the CAS number and formula for Nutlin-3?
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The CAS number for Nutlin-3 is 548472-68-0, and its empirical formula is C30H30Cl2N4O4.
What grade and purity does Tech Serve Solutions supply for Nutlin-3?
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Tech Serve Solutions supplies Nutlin-3 with an assay of ≥98% (HPLC). We do not represent this product as USP, BP, EP, or other pharmacopoeia grades.
How should Nutlin-3 be handled and stored?
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Nutlin-3 is a powder classified with GHS07 signal word 'Warning', with hazard statements H315, H319, and H335. It requires handling with a dust mask type N95 (US), eyeshields, and gloves in a well-ventilated area. Store at -20°C.
How is Nutlin-3 shipped and exported?
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Nutlin-3 is shipped in wet ice to maintain its stability during transit. Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals.
How can I request a quote or sample for Nutlin-3?
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To request a quote or sample for Nutlin-3, please contact our sales team through the website or by phone, referencing the product name and CAS number.
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