Nordihydroguaiaretic acid
Nordihydroguaiaretic acid (CAS: 500-38-9), with the molecular formula [-CH(CH3)CH2C6H3-1,2-(OH)2]2 and a molecular weight of 302.36 g/mol, is a lignan known for its antioxidant properties. It is primarily utilised as a research chemical and biochemical reagent. This compound is also recognised for its role in enzyme inhibition studies, particularly involving lipoxygenase and cyclooxygenase pathways. Tech Serve Solutions supplies this compound with an assay of >97%.
- IUPAC
- 1,4-Bis(3,4-dihydroxyphenyl)-2,3-dimethylbutane,4,4′-(2,3-Dimethyltetramethylene)dipyrocatechol,Masoprocol,NDGA
- Synonyms
- NDGAMasoprocol4,4′-(2,3-Dimethyltetramethylene)dipyrocatechol1,4-Bis(3,4-dihydroxyphenyl)-2,3-dimethylbutane
Biochemical Research
Nordihydroguaiaretic acid serves as a valuable tool in biochemical research due to its potent antioxidant and enzyme inhibitory activities. It is frequently employed in studies investigating cellular signalling pathways and oxidative stress.
Enzyme Inhibition Studies
This compound is extensively used as an inhibitor for enzymes such as lipoxygenase (LOX) and cyclooxygenase (COX). Its application aids in understanding the mechanisms of inflammatory processes and eicosanoid metabolism.
Chemical Synthesis
As an organic building block, Nordihydroguaiaretic acid can be utilised in the synthesis of more complex molecules. Its specific structural features make it a useful starting material in various organic chemistry applications.
Cell Biology
In cell biology, NDGA is applied to investigate the role of reactive oxygen species and lipid peroxidation in cellular functions and disease states. It helps researchers explore the effects of antioxidant interventions.
| Molecular weight | 302.36 |
|---|---|
| Linear formula | [-CH(CH3)CH2C6H3-1,2-(OH)2]2 |
| Assay | >97% |
| Melting point | 184-186 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... ALOX15(246), PTGS1(5742), PTGS2(5743) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Nordihydroguaiaretic acid used for?
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Nordihydroguaiaretic acid is used as a biochemical reagent, particularly in enzyme inhibition studies (e.g., of lipoxygenase and cyclooxygenase pathways), and as an antioxidant in cell biology and biochemical research.
What is the CAS number and molecular formula for Nordihydroguaiaretic acid?
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The CAS number for Nordihydroguaiaretic acid is 500-38-9 and its molecular formula is [-CH(CH3)CH2C6H3-1,2-(OH)2]2.
What grade and purity does Tech Serve Solutions supply for Nordihydroguaiaretic acid?
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Tech Serve Solutions supplies Nordihydroguaiaretic acid with an assay of >97%. We do not represent this product as USP, BP, or EP grade.
How should Nordihydroguaiaretic acid be handled safely?
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Handle Nordihydroguaiaretic acid with appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, and gloves. Ensure good ventilation and avoid breathing dust. It is classified as harmful if swallowed, causes skin irritation, causes serious eye irritation, and may cause respiratory irritation.
How is Nordihydroguaiaretic acid packed and exported?
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Nordihydroguaiaretic acid is carefully packed to maintain its integrity during transit and is available for export globally by Tech Serve Solutions, a specialist supplier since 1998.
How can I request a sample or quote for Nordihydroguaiaretic acid?
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To request a sample or a quote for Nordihydroguaiaretic acid, please contact our sales department via the website or by phone.
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