NKH 477

CAS 138605-00-2C27H43NO8·HClCell Biology

NKH 477 (CAS: 138605-00-2), with the molecular formula C27H43NO8·HCl and a molecular weight of 546.09, is a potent activator of adenylyl cyclase. This bioactive small molecule is primarily utilised in research settings for studies involving cell signaling, neuroscience, and cyclic nucleotide metabolism. It serves as a valuable tool for investigating G protein-coupled receptors and intracellular signalling pathways, particularly those mediated by cyclic AMP.

IUPAC: 6-[3-(dimethylamino)propionyl]-forskolin,Colforsin dapropate hydrochloride,N,N-dimethyl-, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-yl ester b-Alanine hydrochloride
Synonyms: 6-[3-(dimethylamino)propionyl]-forskolin,Colforsin dapropate hydrochloride,N,N-dimethyl-, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-yl ester b-Alanine hydrochloride

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NKH 477 (C27H43NO8·HCl) — chemical structure, CAS 138605-00-2; Life Science, fine chemical supplied by Tech Serve Solutions

Adenylyl Cyclase ActivatorsBioactive Small MoleculesCell BiologyCyclic Nucleotide MetabolismN More...

01 /Applications

Adenylyl Cyclase Activation Studies

NKH 477 is a research-grade chemical used to stimulate adenylyl cyclase activity in biochemical and cellular assays. This activation leads to an increase in intracellular cyclic AMP (cAMP) levels, allowing researchers to study cAMP-dependent signalling pathways.

Cell Signaling Research

As a modulator of cyclic nucleotide metabolism, NKH 477 is employed in understanding cellular responses to various stimuli. Its ability to increase cAMP concentrations aids in deciphering complex cell signaling cascades relevant to diverse physiological processes.

Neuroscience Research Tool

This compound is utilised in neuroscience to explore the role of cAMP in neuronal function and plasticity. Research applications include investigating neurotransmission, learning, and memory mechanisms that involve adenylyl cyclase activity.

02 /Properties

Molecular weight	546.09
Empirical formula	C27H43NO8·HCl
Assay	≥98% (HPLC)
Form	powder
Colour	white to beige
Solubility	H2O: soluble3 mg/mL, clear to slightly hazy (warmed)
Storage temperature	2-8°C

03 /Safety & handling

GHS hazard pictogram: Toxic (GHS06) — Toxic

Danger

Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash thoroughly after handling
P301IF SWALLOWED

Transport (UN / ADR)	UN 2811 6.1 / PGII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	T+
Risk statements (R)	28
Safety statements (S)	28-36/37-45

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

138605-00-2

05 /Additional specifications

Storage Condition	desiccated

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is NKH 477 used for?

NKH 477 is used in research as an activator of adenylyl cyclase, aiding studies in cell signaling, neuroscience, and cyclic nucleotide metabolism.

What are the CAS number and molecular formula for NKH 477?

The CAS number for NKH 477 is 138605-00-2, and its molecular formula is C27H43NO8·HCl.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies NKH 477 with a purity of ≥98% (HPLC). This product is intended for research and laboratory use; TSS does not represent it as USP, BP, or EP grade.

How should NKH 477 be handled safely?

NKH 477 is classified as acutely toxic if swallowed (H300) and requires careful handling. Use appropriate personal protective equipment, including gloves and eye protection, and work in a well-ventilated area. Refer to the Safety Data Sheet for comprehensive handling and disposal information.

How is NKH 477 packed and shipped?

NKH 477 is typically supplied as a white to beige powder. It is stored at 2-8°C and shipped under conditions appropriate for its stability and hazard classification. Tech Serve Solutions exports fine chemicals globally.