Naloxonazine dihydrochloride hydrate
Naloxonazine dihydrochloride hydrate (CAS: 880759-65-9) is a complex organic compound with the molecular formula C38H42N4O6 · 2HCl · xH2O. Characterised as an off-white to light tan powder, it is primarily used as a research chemical in the fields of cell biology, neuroscience, and pharmacology. Its role as an opioid antagonist makes it valuable for studies investigating GPCR modulators and membrane protein biology.
- IUPAC
- bis[(5α)-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-ylidene]hydrazone hydrate dihydrochloride
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Neuroscience Research
Naloxonazine dihydrochloride hydrate serves as a valuable tool in neuroscience research, particularly for studying opioid receptors (OPRM1) and their signalling pathways. It aids in understanding the mechanisms of pain, addiction, and other neurological processes.
Pharmacological Studies
As an opioid antagonist, this compound is employed in pharmacological investigations to probe the effects of opioid agonists and to characterise the function of opioid receptors. Its use is critical for developing a deeper understanding of drug interactions and therapeutic targets.
GPCR Modulation Research
This chemical is utilised in research focused on G protein-coupled receptors (GPCRs), specifically those modulated by opioids. It assists scientists in exploring the complex signalling cascades mediated by these important cell surface receptors.
Cell Biology Investigations
In cell biology, Naloxonazine dihydrochloride hydrate can be used to investigate cellular responses to opioid receptor activation or blockade. This aids in understanding cellular signalling and function within biological systems.
| Molecular weight | 723.69 (anhydrous basis) |
|---|---|
| Empirical formula | C38H42N4O6 · 2HCl · xH2O |
| Assay | ≥95% (HPLC) |
| Form | powder |
| Colour | off-white to light tan |
| Solubility | H2O: >2 mg/mL |
| Storage temperature | −20°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Drug Control | regulated under CDSA - not available from Canada |
|---|---|
| Gene Information | human ... OPRM1(4988) |
| Storage Condition | desiccated |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Naloxonazine dihydrochloride hydrate used for?
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Naloxonazine dihydrochloride hydrate is primarily used as a research chemical in neuroscience, pharmacology, and cell biology, particularly for studying opioid receptors and GPCR modulation.
What is the CAS number and formula for Naloxonazine dihydrochloride hydrate?
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The CAS number for the anhydrous form is 880759-65-9. The empirical formula is C38H42N4O6 · 2HCl · xH2O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Naloxonazine dihydrochloride hydrate with an assay of ≥95% (HPLC). TSS does not represent this product as USP, BP, EP, or other pharmacopoeia grades.
How should Naloxonazine dihydrochloride hydrate be handled safely?
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Handle Naloxonazine dihydrochloride hydrate with appropriate personal protective equipment, including eyeshields, gloves, and a type N95 (US) or type P1 (EN143) respirator filter. Refer to the safety data sheet for comprehensive handling information. The WGK Germany is 3.
Is Naloxonazine dihydrochloride hydrate a controlled substance?
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Yes, this compound is regulated under CDSA and is not available from Canada. It is a controlled substance.
How is Naloxonazine dihydrochloride hydrate shipped and exported?
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Naloxonazine dihydrochloride hydrate is typically supplied as an off-white to light tan powder and stored under desiccated conditions at -20°C. TSS exports chemicals globally, adhering to all relevant shipping regulations for controlled substances.
How can I request a quote or sample?
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To request a quote or a sample of Naloxonazine dihydrochloride hydrate, please contact the Tech Serve Solutions sales team through our website or by phone.
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