Nalbuphine hydrochloride hydrate
Nalbuphine hydrochloride hydrate (CAS 23277-43-2 anhydrous) is a synthetic opioid analgesic with mixed agonist-antagonist properties. This compound is structurally related to naloxone and acts as a kappa-opioid receptor agonist and a mu-opioid receptor antagonist. It is primarily utilized in research settings for its pharmacological activity and as a tool for studying opioid receptor systems. Its chemical formula is C21H27NO4 · HCl · xH2O, with a molecular weight of 393.90 g/mol on an anhydrous basis.
- IUPAC
- 17-(Cyclobutylmethyl)-4,5-epoxymorphinan-3,6,14-triol hydrochloride hydrate
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Pharmacological Research
Used as a research chemical to investigate opioid receptor interactions, particularly the balance between kappa-agonism and mu-antagonism. It serves as a valuable tool for understanding pain pathways and the mechanisms of analgesia.
Drug Discovery and Development
As an approved therapeutic, it can be studied for its potential in developing new analgesics or other therapeutics targeting the opioid system. Researchers explore its efficacy and safety profiles in preclinical models.
Neuroscience Research
Investigated for its effects on the central nervous system, particularly in relation to neurotransmission and the modulation of pain perception. Its distinct receptor binding profile makes it relevant for neuroscience studies.
| Molecular weight | 393.90 (anhydrous basis) |
|---|---|
| Empirical formula | C21H27NO4 · HCl · xH2O |
| Assay | ≥98% (HPLC) |
| Solubility | H2O: solubleethanol: soluble |
Hazard statements
- H300Fatal if swallowed
- H310Fatal in contact with skin
- H330Fatal if inhaled
Precautionary statements
- P260Do not breathe dust, fume, gas, mist, vapours or spray
- P264Wash thoroughly after handling
- P280Wear protective gloves, clothing and eye/face protection
- P284Wear respiratory protection
- P302IF ON SKIN
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T+ |
| Risk statements (R) | 26/27/28 |
| Safety statements (S) | 22-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Drug Control | regulated under CDSA - not available from Canada |
|---|---|
| Gene Information | human ... OPRK1(4986), OPRM1(4988) |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Nalbuphine hydrochloride hydrate used for?
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Nalbuphine hydrochloride hydrate is primarily used in pharmacological and neuroscience research to study opioid receptor systems due to its mixed agonist-antagonist properties. It is also a component of approved therapeutics.
What is the CAS number and formula for Nalbuphine hydrochloride hydrate?
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The CAS number for the anhydrous form is 23277-43-2. The empirical formula is C21H27NO4 · HCl · xH2O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Nalbuphine hydrochloride hydrate with a purity of ≥98% (HPLC). This product is intended for research purposes and is not represented as USP, BP, or EP grade.
How should Nalbuphine hydrochloride hydrate be handled?
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Handle Nalbuphine hydrochloride hydrate with extreme caution. It is classified as acutely toxic via ingestion, dermal contact, and inhalation (H300, H310, H330). Always use appropriate personal protective equipment, including eyeshields, face shields, gloves, and a full-face particle respirator (N100 or equivalent), and work in a well-ventilated area or fume hood.
Is Nalbuphine hydrochloride hydrate a controlled substance?
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Yes, Nalbuphine hydrochloride hydrate is regulated under the Controlled Drugs and Substances Act (CDSA) and is not available for export from Canada.
How can I request a sample or quote for Nalbuphine hydrochloride hydrate?
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To request a sample or obtain a quote for Nalbuphine hydrochloride hydrate, please contact our sales team through the website or by phone. Provide your contact details and the quantity required.
What are the shipping and export restrictions for Nalbuphine hydrochloride hydrate?
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Nalbuphine hydrochloride hydrate is a controlled substance and is subject to stringent shipping regulations (UN 2811, Class 6.1, PG II). Export is restricted, and availability may vary by region. Please contact us for specific details regarding your location.
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