N-Succinyl-Leu-Leu-Val-Tyr-7-Amido-4-Methylcoumarin

CAS 94367-21-2C40H53N5O10Biochemicals & Reagents

N-Succinyl-Leu-Leu-Val-Tyr-7-Amido-4-Methylcoumarin (CAS: 94367-21-2) is a fluorometric substrate with the empirical formula C40H53N5O10 and a molecular weight of 763.88 g/mol. This compound is primarily employed as a tool in biochemical research for assessing enzyme activity, particularly in the study of proteasomes and other related enzymatic pathways within cellular systems. It serves as a sensitive indicator in various biological assays.

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N-Succinyl-Leu-Leu-Val-Tyr-7-Amido-4-Methylcoumarin (C40H53N5O10) — chemical structure, CAS 94367-21-2; Life Science, fine chemical supplied by Tech Serve Solutions

Apoptosis EnzymesApplication IndexBioactive Small MoleculesBiochemicals and ReagentsCalpainCathepsin BCell BiologyCell Signaling EnzymesEnzyme SubstratesEnzymes

01 /Applications

Proteasome Chymotrypsin-Like Activity Assay

Utilised as a fluorometric substrate to measure the chymotrypsin-like activity of proteasomes. It has been applied in assays using Jurkat cell lysate, providing a quantitative measure of this enzymatic function.

Enzyme Activity Assays in Biological Samples

The compound serves as a versatile substrate for investigating enzyme kinetics and activity in various biological matrices. Its use in crude cell lysate, such as from rice, highlights its applicability across different biological systems.

Biochemical Research Tool

N-Succinyl-Leu-Leu-Val-Tyr-7-Amido-4-Methylcoumarin functions as a valuable reagent in general biochemical research. It aids in the characterisation and study of enzymes involved in cellular processes, signalling, and degradation pathways.

02 /Properties

Molecular weight	763.88
Empirical formula	C40H53N5O10
Assay	≥90% (HPLC)
Storage temperature	−20°C
Application	N-succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin was used in proteasome chymotrypsin-like activity assay in Jurkat cell lysate6 and crude cell lysate of rice.7

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

94367-21-2

MDL number

MFCD00080248

PubChem substance

24899709

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is N-Succinyl-Leu-Leu-Val-Tyr-7-Amido-4-Methylcoumarin used for?

N-Succinyl-Leu-Leu-Val-Tyr-7-Amido-4-Methylcoumarin is used as a fluorometric substrate in biochemical research, particularly for assays measuring proteasome chymotrypsin-like activity and other enzymatic functions in cell lysates.

What is the CAS number and empirical formula?

The CAS number is 94367-21-2 and the empirical formula is C40H53N5O10.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies N-Succinyl-Leu-Leu-Val-Tyr-7-Amido-4-Methylcoumarin with a purity of ≥90% by HPLC. TSS does not represent this product as USP, BP, EP or any other pharmacopoeial grade.

How should this chemical be handled and stored?

Handle with appropriate personal protective equipment including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. Store at -20°C.

What are the GHS hazards for this chemical?

This chemical has a WGK Germany rating of 3, indicating it is hazardous to the aquatic environment.

How can I request a sample or quote?

Please contact our sales team via the website or your usual representative to request a sample or quote for N-Succinyl-Leu-Leu-Val-Tyr-7-Amido-4-Methylcoumarin.