N,N-Diisopropylmethylphosphonamidic chloride

CAS 86030-43-5[(CH3)2CH]2NP(OCH3)ClCatalysis & Inorganic

N,N-Diisopropylmethylphosphonamidic chloride (CAS: 86030-43-5) is a chemical compound with the linear formula [(CH3)2CH]2NP(OCH3)Cl and a molecular weight of 197.64 g/mol. This reagent is primarily utilised in chemical synthesis, particularly for the preparation of polymer-supported deoxyoligonucleotides and oligoribonucleotides. Its properties make it a valuable component in advanced organic and inorganic chemistry applications requiring phosphorus precursors.

IUPAC: Chloro(diisopropylamino)methoxyphosphine,Methyl N,N-diisopropylchlorophosphoramidite,Methyl N,N-diisopropylphosphoramidochloridite
Synonyms: Chloro(diisopropylamino)methoxyphosphineMethyl N,N-diisopropylchlorophosphoramiditeMethyl N,N-diisopropylphosphoramidochloridite

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N,N-Diisopropylmethylphosphonamidic chloride ([(CH3)2CH]2NP(OCH3)Cl) — chemical structure, CAS 86030-43-5; Chemistry, fine chemical supplied by Tech Serve Solutions

Chemical SynthesisPhosphine CompoundsPhosphorus Precursors

01 /Applications

Oligonucleotide Synthesis

This compound serves as a key reagent in the synthesis of both deoxyoligonucleotides and oligoribonucleotides. It is instrumental in creating polymer-supported versions of these essential biomolecules for various research applications.

Chemical Synthesis Reagent

As a phosphorus precursor, it is employed in diverse chemical synthesis pathways. Its reactivity profile allows for specific modifications and constructions in organic and inorganic chemistry research.

Phosphine Compound Intermediate

N,N-Diisopropylmethylphosphonamidic chloride functions as an intermediate in the synthesis of more complex phosphine compounds. This role is crucial in developing novel materials and catalysts.

02 /Properties

Molecular weight	197.64
Linear formula	[(CH3)2CH]2NP(OCH3)Cl
Assay	95%
Boiling point	34-35 °C/0.8 mmHg(lit.)
Density	1.018 g/mL at 25 °C(lit.)
Refractive index	n20/D 1.468(lit.)
Application	Reagent used for polymer-supported deoxyoligonucleotide1 and oligoribonucleotide2,3 syntheses.

03 /Safety & handling

GHS hazard pictogram: Corrosive (GHS05) — Corrosive

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves, clothing and eye/face protection
P305IF IN EYES
P310Immediately call a POISON CENTER or doctor

Protective equipment	Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Flash point	72 °C / 161.6 °F
Transport (UN / ADR)	UN 3265 8 / PGII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	C
Risk statements (R)	34
Safety statements (S)	26-36/37/39-45

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

86030-43-5

MDL number

MFCD00009859

PubChem substance

24855746

Beilstein registry

3600769

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is N,N-Diisopropylmethylphosphonamidic chloride used for?

N,N-Diisopropylmethylphosphonamidic chloride is used as a reagent in polymer-supported deoxyoligonucleotide and oligoribonucleotide syntheses. It is also valuable in general chemical synthesis as a phosphorus precursor.

What are the CAS number and formula for N,N-Diisopropylmethylphosphonamidic chloride?

The CAS number is 86030-43-5 and the linear formula is [(CH3)2CH]2NP(OCH3)Cl.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies N,N-Diisopropylmethylphosphonamidic chloride with an assay of 95%. We do not represent this product as USP, BP, EP, or any pharmacopoeia grade.

What are the safety considerations when handling N,N-Diisopropylmethylphosphonamidic chloride?

This compound is classified under GHS05 with the signal word 'Danger' and hazard statement H314, indicating it causes severe skin burns and eye damage. Appropriate personal protective equipment, including a full-face respirator, gloves, and goggles, is essential. Handle with extreme care in a well-ventilated area.

How is N,N-Diisopropylmethylphosphonamidic chloride packed, shipped, and exported?

N,N-Diisopropylmethylphosphonamidic chloride is packed and shipped in compliance with international regulations for hazardous materials. As a global supplier, Tech Serve Solutions has extensive experience in exporting this chemical worldwide.

How can I request a sample or quote for N,N-Diisopropylmethylphosphonamidic chloride?

To request a sample or a quotation, please contact our sales department through the website or by phone. Our team will assist you with your specific requirements.