N-Methoxy-N-methyl-2,2,2-trifluoroacetamide
N-Methoxy-N-methyl-2,2,2-trifluoroacetamide (CAS: 104863-67-4) is a fluorinated organic compound with the molecular formula C4H6F3NO2 and a molecular weight of 157.09 g/mol. It serves as a valuable building block and intermediate in organic synthesis, particularly for introducing trifluoroacetyl groups. This compound is typically supplied at a purity of 98%, suitable for research and chemical synthesis applications. Its chemical properties make it a useful reagent in various chemical transformations.
- IUPAC
- N-Methyl-N-methoxytrifluoroacetamide
- Synonyms
- 104863-67-4C4H6F3NO2N-Methoxy-N-methyltrifluoroacetamideN-Methyl-N-methoxytrifluoroacetamide

Organic Synthesis Intermediate
N-Methoxy-N-methyl-2,2,2-trifluoroacetamide acts as a key intermediate in the synthesis of complex organic molecules. Its trifluoroacetyl moiety can be readily transferred in various chemical reactions.
Fluorination Reagent
This compound can be employed as a reagent for introducing trifluoromethyl groups or trifluoroacetyl functionalities into organic structures. This is crucial for developing novel pharmaceuticals and agrochemicals.
Building Block for Specialty Chemicals
As an organic building block, it facilitates the construction of specialised chemical entities. Its unique structure is leveraged in academic and industrial research laboratories for creating new chemical entities.
| Molecular weight | 157.09 |
|---|---|
| Empirical formula | C4H6F3NO2 |
| Assay | 98% |
| Boiling point | 53 °C/30 mmHg(lit.) |
| Density | 1.299 g/mL at 25 °C(lit.) |


Hazard statements
- H226Flammable liquid and vapour
- H301Toxic if swallowed
- H319Causes serious eye irritation
Precautionary statements
- P301IF SWALLOWED
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 47 °C / 116.6 °F |
| Transport (UN / ADR) | UN 1992 3/PG 3 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 10-25-36 |
| Safety statements (S) | 16-26-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-Methoxy-N-methyl-2,2,2-trifluoroacetamide used for?
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N-Methoxy-N-methyl-2,2,2-trifluoroacetamide is primarily used as an intermediate and building block in organic synthesis, particularly for introducing trifluoroacetyl groups into other molecules. It is valuable in the development of pharmaceuticals and agrochemicals.
What is the CAS number and formula for N-Methoxy-N-methyl-2,2,2-trifluoroacetamide?
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The CAS number for N-Methoxy-N-methyl-2,2,2-trifluoroacetamide is 104863-67-4, and its empirical formula is C4H6F3NO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies N-Methoxy-N-methyl-2,2,2-trifluoroacetamide with an assay of 98%. We do not represent this product as USP, BP, EP, or pharmacopoeia grade.
How should N-Methoxy-N-methyl-2,2,2-trifluoroacetamide be handled safely?
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N-Methoxy-N-methyl-2,2,2-trifluoroacetamide is classified as Danger (GHS02, GHS06) with hazards H226 (Flammable liquid and vapour) and H301 (Toxic if swallowed). It also carries H319 (Causes serious eye irritation). Handle with appropriate personal protective equipment including eyeshields, face shields, gloves, and a suitable respirator. Ensure good ventilation and avoid ignition sources. Store in a cool, well-ventilated place, away from heat and ignition sources.
How is N-Methoxy-N-methyl-2,2,2-trifluoroacetamide packed and shipped?
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This product is typically packed in accordance with international shipping regulations for hazardous materials. As a flammable and toxic liquid, it is shipped as UN 1992, 3/PG 3. We export globally, adhering to all relevant transport and customs requirements.
How can I request a sample or quote for N-Methoxy-N-methyl-2,2,2-trifluoroacetamide?
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To request a sample or a quote, please contact our sales department through the website or by phone. Provide the product name, CAS number, and the quantity required for a prompt response.
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