N-Fmoc-isocyanate
N-Fmoc-isocyanate (CAS 232951-82-5), with the molecular formula C16H11NO3 and a molecular weight of 265.26 g/mol, is a specialised organic building block. It is primarily utilised in chemical synthesis, serving as a key reagent in the introduction of the Fmoc protecting group. This compound's reactivity makes it valuable in peptide synthesis and other complex organic transformations where selective protection and deprotection strategies are essential.
- IUPAC
- N-(9-Fluorenylmethoxycarbonyl)isocyanate,Carbonisocyanatidic acid 9H-fluoren-9-ylmethyl ester,Fluoren-9-ylmethyloxycarbonylisocyanate
- Synonyms
- N-(9-Fluorenylmethoxycarbonyl)isocyanateCarbonisocyanatidic acid 9H-fluoren-9-ylmethyl esterFluoren-9-ylmethyloxycarbonylisocyanate
Peptide Synthesis
N-Fmoc-isocyanate is instrumental in solid-phase and solution-phase peptide synthesis for the efficient introduction of the fluorenylmethoxycarbonyl (Fmoc) protecting group onto amino acids. This protection strategy is crucial for controlling reactivity during complex peptide chain elongation.
Organic Synthesis Reagent
As a versatile isocyanate, it participates in various organic reactions, enabling the formation of carbamates and other derivatives. Its utility extends to the synthesis of complex organic molecules and pharmaceutical intermediates.
Research and Development
This compound finds application in academic and industrial research settings for exploring novel synthetic routes and developing new chemical entities. Its specific reactivity profile aids in advanced chemical research.
| Molecular weight | 265.26 |
|---|---|
| Empirical formula | C16H11NO3 |
| Assay | 95% |
| Storage temperature | −20°C |
| Melting point | 52-56 °C |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
- H400Very toxic to aquatic life
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P273Avoid release to the environment
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Flash point | >110 °C / >230 °F |
|---|---|
| Transport (UN / ADR) | UN 2206 6.1/PG 3 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38-50/53 |
| Safety statements (S) | 26-36/37-60-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-Fmoc-isocyanate used for?
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N-Fmoc-isocyanate is primarily used as a reagent in chemical synthesis, particularly for the introduction of the Fmoc protecting group in peptide synthesis and the creation of other organic molecules.
What are the CAS number and formula for N-Fmoc-isocyanate?
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The CAS number for N-Fmoc-isocyanate is 232951-82-5, and its molecular formula is C16H11NO3.
What grade and purity does Tech Serve Solutions supply for N-Fmoc-isocyanate?
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Tech Serve Solutions supplies N-Fmoc-isocyanate with an assay of 95%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should N-Fmoc-isocyanate be handled safely?
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N-Fmoc-isocyanate is a Warning substance. It is harmful if swallowed, in contact with skin, or if inhaled, and causes skin irritation, serious eye irritation, and respiratory irritation. It is also toxic to aquatic life with long-lasting effects. Handle with appropriate personal protective equipment in a well-ventilated area, avoiding release to the environment.
How is N-Fmoc-isocyanate packed, shipped, and exported?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, capable of meeting diverse shipping and export requirements for N-Fmoc-isocyanate. Please contact us for specific details regarding packaging and logistics.
How can I request a sample or quote for N-Fmoc-isocyanate?
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To request a sample or a quotation for N-Fmoc-isocyanate, please visit our website or contact our sales department directly.
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