N-Acetyl-D-penicillamine
N-Acetyl-D-penicillamine (CAS: 15537-71-0), with the molecular formula C7H13NO3S and a molecular weight of 191.25 g/mol, is a modified amino acid. This chiral reagent is primarily utilised for the precolumn derivatization of amino acids and amino alcohols. It enables the efficient resolution of formed diastereoisomers using conventional reversed-phase High-Performance Liquid Chromatography (HPLC).
- IUPAC
- N-Acetyl-3-mercapto-D-valine,NAP,NAPA
- Synonyms
- N-Acetyl-3-mercapto-D-valine, NAP, NAPA
Chiral Derivatization for HPLC
N-Acetyl-D-penicillamine serves as a valuable chiral derivatization reagent. It reacts with amino acids and amino alcohols to form diastereoisomers that can be separated and quantified using standard reversed-phase HPLC techniques.
Amino Acid Analysis
In analytical chemistry, it is employed for the improved chromatographic separation of enantiomeric amino acids. The derivatization process enhances detectability and resolution, critical for accurate amino acid profiling.
Biochemical Research
As a modified amino acid derivative, it finds application in biochemical research, particularly in studies involving peptide chemistry and the analysis of biologically relevant molecules.
| Molecular weight | 191.25 |
|---|---|
| Empirical formula | C7H13NO3S |
| Assay | ≥99.0% (T) |
| Grade | for HPLC derivatization |
| Optical activity | [α]20/D +10±2°, c = 1% in ethanol |
| Application | Chiral reagent for the precolumn derivatization of amino acids or amino alcohols; the diastereoisomers formed can be efficiently resolved by HPLC on conventional reversed-phase columns1 |
| Melting point | 185-190 °C (dec.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-Acetyl-D-penicillamine used for?
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N-Acetyl-D-penicillamine is used as a chiral reagent for the precolumn derivatization of amino acids and amino alcohols to enable their resolution by HPLC.
What is the CAS number and molecular formula for N-Acetyl-D-penicillamine?
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The CAS number is 15537-71-0, and the molecular formula is C7H13NO3S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies N-Acetyl-D-penicillamine with an assay of ≥99.0% (T) and a grade specifically for HPLC derivatisation. We do not represent this product as USP, BP, or EP grade.
How should N-Acetyl-D-penicillamine be handled safely?
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N-Acetyl-D-penicillamine is classified with a Warning signal word and carries hazard statements H315, H319, and H335, indicating it causes skin irritation, serious eye irritation, and may cause respiratory irritation. Appropriate personal protective equipment, including a dust mask (type N95), eyeshields, and gloves, should be used. Ensure adequate ventilation and avoid breathing dust. Recommended precautionary statements include P261 and P305 + P351 + P338.
How is N-Acetyl-D-penicillamine packed and exported?
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N-Acetyl-D-penicillamine is carefully packed to maintain its integrity during transit and is exported globally by Tech Serve Solutions, adhering to all necessary regulations.
How can I request a quote or sample for N-Acetyl-D-penicillamine?
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To request a quote or sample of N-Acetyl-D-penicillamine, please contact the Tech Serve Solutions sales team through our website or by phone.
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