N-[4-(tert-Butyl-dimethyl-silanyloxymethyl)-pyridin-2-yl]-2,2-dimethyl-propionamide
N-[4-(tert-Butyl-dimethyl-silanyloxymethyl)-pyridin-2-yl]-2,2-dimethyl-propionamide (CAS 618107-92-9, C17H30N2O2Si, molar mass 322.52) is an organosilicon pyridine building block. It pairs a TBS (tert-butyldimethylsilyl) ether-protected hydroxymethyl group at the 4-position with a pivaloyl amide on the 2-aminopyridine. This dual protection makes it a versatile intermediate for the directed metalation and functionalisation of pyridine scaffolds in pharmaceutical and fine-chemical synthesis. Tech Serve Solutions supplies it as a research-grade reagent for synthetic chemistry programmes.
- Synonyms
- N-[4-(tert-Butyl-dimethyl-silanyloxymethyl)-pyridin-2-yl]-2,2-dimethyl-propionamideN-{4-[(tert-Butyldimethylsilyloxy)methyl]pyridin-2-yl}-2,2-dimethylpropanamideN-(4-(((tert-Butyldimethylsilyl)oxy)methyl)pyridin-2-yl)pivalamide2,2-Dimethyl-N-[4-[[[tert-butyl(dimethyl)silyl]oxy]methyl]pyridin-2-yl]propanamideCAS 618107-92-9
![N-[4-(tert-Butyl-dimethyl-silanyloxymethyl)-pyridin-2-yl]-2,2-dimethyl-propionamide (C17H30N2O2Si) — chemical structure, CAS 618107-92-9; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F618107-92-9.png&w=3840&q=75)
Pyridine building block for synthesis
Serves as a multi-functional heterocyclic intermediate for constructing substituted 2-aminopyridine and pyridinemethanol scaffolds. The protected handles allow selective, stepwise elaboration in medicinal and fine-chemical chemistry.
Protected hydroxymethyl handle
The tert-butyldimethylsilyl (TBS) ether masks a benzylic-type hydroxymethyl group, giving a stable yet readily cleavable point for later deprotection and onward functional-group interconversion.
Pivaloyl-directed functionalisation
The 2,2-dimethylpropionamide (pivaloyl) group both protects the 2-amino position and can act as a directing group for regioselective metalation or C-H functionalisation of the pyridine ring.
Pharmaceutical intermediate
Used in early-stage and process research as an organosilicon building block towards pyridine-containing active pharmaceutical ingredients and candidate molecules. Specific routes depend on the customer's target.
Research and method development
Suitable for laboratory-scale route scouting, organometallic reagent preparation and protecting-group strategy studies where a doubly protected aminopyridinemethanol motif is required.
| Molecular weight | 322.52 |
|---|---|
| Empirical formula | C17H30N2O2Si |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-[4-(tert-Butyl-dimethyl-silanyloxymethyl)-pyridin-2-yl]-2,2-dimethyl-propionamide used for?
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It is used as an organosilicon pyridine building block in chemical synthesis. The TBS-protected hydroxymethyl group and the pivaloyl-protected 2-amino group make it a versatile intermediate for the regioselective functionalisation of pyridine scaffolds in pharmaceutical and fine-chemical research.
What is the CAS number and molecular formula of N-[4-(tert-Butyl-dimethyl-silanyloxymethyl)-pyridin-2-yl]-2,2-dimethyl-propionamide?
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The CAS number is 618107-92-9. The empirical formula is C17H30N2O2Si (Hill notation) with a molecular weight of 322.52 g/mol.
What grade and purity does Tech Serve Solutions supply?
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We supply this compound as a research-grade reagent for synthetic chemistry. The verified specification gives a molecular weight of 322.52 for formula C17H30N2O2Si; a batch-specific assay is confirmed on the certificate of analysis. We do not represent this product as USP, BP or EP pharmacopoeial grade.
How should this compound be handled and stored?
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No GHS classification data is supplied for this item, so it should be treated as a research chemical of undetermined hazard: handle only as a trained chemist, use appropriate PPE, avoid skin and eye contact and dust or vapour, and work in a fume hood. As a silyl ether, keep it cool, dry and tightly closed away from moisture. Always consult our latest Safety Data Sheet before use.
How is N-[4-(tert-Butyl-dimethyl-silanyloxymethyl)-pyridin-2-yl]-2,2-dimethyl-propionamide packed, shipped and exported?
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It is packed in sealed, appropriately labelled laboratory containers sized from gram to bulk quantities, with packaging chosen to protect the material from moisture. Tech Serve Solutions exports worldwide with full documentation, including a certificate of analysis and Safety Data Sheet, in line with applicable transport regulations.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity and intended use, quoting product 114845 or CAS 618107-92-9. We will respond with availability, lead time, documentation and a formal quotation.
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