N-(4-Hydroxybutyl)trifluoroacetamide
N-(4-Hydroxybutyl)trifluoroacetamide (CAS: 128238-43-7) is a fluorinated organic compound with the molecular formula C6H10F3NO2. This bifunctional molecule serves as a versatile building block in chemical synthesis. Its structure, featuring both a hydroxyl group and a trifluoroacetylated amine, allows for selective derivatization, making it valuable in the development of complex organic molecules and functionalised materials. TSS supplies this chemical for research and development purposes.
- IUPAC
- 4-(Trifluoroacetamido)-1-butanol

Organic Synthesis Intermediate
N-(4-Hydroxybutyl)trifluoroacetamide is utilised as a key intermediate in the synthesis of more complex organic molecules. The presence of both a primary alcohol and a protected amine functionality allows for sequential reactions and the introduction of the trifluoroacetyl group into target structures.
Bifunctional Linker
The compound can act as a bifunctional linker, connecting different molecular entities through reactions at its hydroxyl and amine sites. This is particularly useful in the design of novel materials or in bioconjugation strategies.
Building Block for Specialty Chemicals
Its unique structure makes it a valuable building block for the creation of specialty chemicals and advanced intermediates within the pharmaceutical and chemical industries. The trifluoroacetyl group can impart specific chemical and physical properties.
| Molecular weight | 185.14 |
|---|---|
| Empirical formula | C6H10F3NO2 |
| Assay | ≥98.0% (GC) |
| Density | 1.262 g/mL at 20 °C(lit.) |
| Refractive index | n20/D 1.413 |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-(4-Hydroxybutyl)trifluoroacetamide used for?
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N-(4-Hydroxybutyl)trifluoroacetamide is primarily used as an intermediate and building block in organic synthesis, particularly for creating more complex molecules and bifunctionalised compounds. It is also employed in chemical biology and the synthesis of specialty chemicals.
What is the CAS number and molecular formula?
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The CAS number for N-(4-Hydroxybutyl)trifluoroacetamide is 128238-43-7, and its molecular formula is C6H10F3NO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies N-(4-Hydroxybutyl)trifluoroacetamide with an assay of ≥98.0% (GC). TSS does not represent this product as USP, BP, EP, or other pharmacopoeial grades.
How should N-(4-Hydroxybutyl)trifluoroacetamide be handled safely?
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Based on GHS classifications, N-(4-Hydroxybutyl)trifluoroacetamide is a warning substance that may cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator, should be used. Avoid breathing dust/fume/gas/mist/vapours/spray. In case of contact with eyes, rinse cautiously with water for several minutes.
Is this chemical a controlled substance?
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The provided data does not indicate that N-(4-Hydroxybutyl)trifluoroacetamide is a controlled substance.
How is N-(4-Hydroxybutyl)trifluoroacetamide packed, shipped, and exported?
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N-(4-Hydroxybutyl)trifluoroacetamide is packed and shipped in accordance with standard chemical handling and international shipping regulations for hazardous materials. TSS exports chemicals globally to qualified research institutions and industrial clients.
How can I request a sample or quote for N-(4-Hydroxybutyl)trifluoroacetamide?
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To request a sample or a quotation for N-(4-Hydroxybutyl)trifluoroacetamide, please contact the TSS sales department via our website or directly by phone.
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