Mithramycin A from Streptomyces plicatus

CAS 18378-89-7C52H76O24Biochemicals & Reagents

Mithramycin A (CAS: 18378-89-7), with the empirical formula C52H76O24 and a molecular weight of 1085.15 g/mol, is a naturally occurring aureolic acid antibiotic isolated from *Streptomyces plicatus*. It functions as an antineoplastic agent by inhibiting RNA synthesis. Mithramycin A is a complex polyketide and glycoside, recognised for its biological activity and potential therapeutic applications in oncology.

IUPAC: Aureolic acid,Plicamycin
Synonyms: Plicamycin

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Mithramycin A from Streptomyces plicatus (C52H76O24) — chemical structure, CAS 18378-89-7; Life Science, fine chemical supplied by Tech Serve Solutions

AntibioticsAntibiotics A to ZAntibiotics G-MAntibiotics by ApplicationAureolic AcidsBioactive Small MoleculesBiochemicals and ReagentsCell BiologyChemical Structure ClassDrug Efflux Pumps

01 /Applications

Antineoplastic Research

Mithramycin A is utilised in research settings for its cytotoxic properties, primarily investigating its mechanisms as an inhibitor of RNA synthesis and its potential in cancer therapy development.

Biochemical Research Tool

This compound serves as a valuable tool in molecular biology and biochemistry for studying transcription regulation and DNA-binding interactions, owing to its ability to bind GC-rich regions of DNA.

Drug Discovery and Development

Its unique mechanism of action makes Mithramycin A a subject of interest in drug discovery programs aimed at identifying novel antineoplastic agents or understanding drug resistance pathways.

02 /Properties

Molecular weight	1085.15
Empirical formula	C52H76O24
Assay	≥90% (HPLC)
Storage temperature	2-8°C

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H302Harmful if swallowed

Protective equipment	dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xn
Risk statements (R)	22

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

18378-89-7

MDL number

MFCD00135618

PubChem substance

24897127

Beilstein registry

5236667

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Mithramycin A used for?

Mithramycin A is primarily used in antineoplastic research and as a biochemical research tool for studying transcription and DNA interactions. It inhibits RNA synthesis and exhibits cytotoxic properties.

What are the CAS number and formula for Mithramycin A?

The CAS number for Mithramycin A is 18378-89-7, and its empirical formula is C52H76O24.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Mithramycin A with an assay of ≥90% by HPLC. We do not represent this product as USP, BP, EP, or pharmaceutical grade.

What are the safety considerations for handling Mithramycin A?

Mithramycin A is classified with a GHS07 symbol and a Warning signal word, indicating it is harmful if swallowed (H302). Appropriate personal protective equipment, including a dust mask (type N95), eyeshields, faceshields, and gloves, should be used during handling.

How is Mithramycin A shipped and exported by Tech Serve Solutions?

Mithramycin A is stored at 2-8°C. Tech Serve Solutions, as a specialist global supplier and exporter, ensures appropriate packaging and handling for international shipment.