Metolazone

CAS 17560-51-9C16H16ClN3O3SCell Biology

Metolazone (CAS: 17560-51-9, C16H16ClN3O3S) is a white solid compound with a molecular weight of 365.83 g/mol. As a thiazide-like diuretic, it is primarily utilised in pharmaceutical research and development for its therapeutic applications in managing fluid retention associated with conditions such as heart failure and hypertension. Its specific chemical structure and biological activity make it a valuable molecule for studying ion transport mechanisms.

IUPAC: 7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide

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Metolazone (C16H16ClN3O3S) — chemical structure, CAS 17560-51-9; Life Science, fine chemical supplied by Tech Serve Solutions

Bioactive Small MoleculesCell BiologyIon ChannelsMonovalent Ion ChannelsPfizer CompoundsSodium Channel ModulatorsUCB Inc.

01 /Applications

Diuretic Agent Research

Metolazone serves as a key compound in research exploring the mechanisms of diuretic action and fluid balance regulation. It is used to investigate its effects on renal function and electrolyte excretion.

Cardiovascular Research

This compound is employed in studies related to hypertension and oedema, where its ability to modulate sodium and water reabsorption in the kidneys is of particular interest for understanding cardiovascular disease management.

Ion Channel Modulation Studies

As a modulator of sodium channels, Metolazone is utilized in fundamental research to understand the function and regulation of these critical ion transport proteins in various physiological and pathological contexts.

02 /Properties

Molecular weight	365.83
Empirical formula	C16H16ClN3O3S
Assay	≥98% (HPLC)
Form	solid
Colour	white
Solubility	DMSO: >5 mg/mL

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	2

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

17560-51-9

MDL number

MFCD00069304

05 /Additional specifications

Gene Information	human ... SLC12A1(6557)

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is Metolazone used for?

Metolazone is used in research for its properties as a diuretic and for studying its effects on cardiovascular conditions, hypertension, and ion channel modulation.

What is the CAS number and formula for Metolazone?

The CAS number for Metolazone is 17560-51-9, and its empirical formula is C16H16ClN3O3S.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Metolazone with a purity of ≥98% (HPLC). We do not represent this product as USP, BP, or EP grade unless explicitly stated.

What are the safety and handling precautions for Metolazone?

When handling Metolazone, it is essential to wear safety eyewear and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used. Refer to the safety data sheet for comprehensive hazard information.

How is Metolazone packed and shipped?

Metolazone is typically supplied as a white solid. Tech Serve Solutions exports chemicals globally, adhering to all necessary shipping and handling regulations.