Methylmagnesium chloride solution
Methylmagnesium chloride solution (CAS: 676-58-4, CH₃MgCl) is a highly reactive organometallic compound supplied by TSS. As a Grignard reagent, it is a potent nucleophile and a strong base, crucial for carbon-carbon bond formation in organic synthesis. It is commonly used to introduce a methyl group into organic molecules, facilitating the creation of more complex structures in pharmaceuticals, agrochemicals, and materials science. Supplied as a solution in Tetrahydrofuran (THF).
Carbon-Carbon Bond Formation
Methylmagnesium chloride serves as a key Grignard reagent for nucleophilic addition to carbonyl compounds (aldehydes, ketones, esters) and epoxides. This reaction is fundamental for building carbon skeletons in the synthesis of complex organic molecules.
Methyl Group Introduction
This reagent is efficiently used to transfer a methyl group to various organic substrates. This is a vital transformation in the synthesis pathways for pharmaceuticals, fragrances, and speciality chemicals.
Organometallic Synthesis
As a representative organometallic reagent, it participates in a wide array of reactions beyond simple alkylation, enabling access to diverse chemical functionalities and structures.
| Molecular weight | 74.79 |
|---|---|
| Linear formula | CH3MgCl |
| Density | 1.013 g/mL at 25 °C |
| Concentration | 3.0 M in THF |
| Autoignition temp | 609 °F |
Hazard statements
- H225Highly flammable liquid and vapour
- H260In contact with water releases flammable gases
- H314Causes severe skin burns and eye damage
- H335May cause respiratory irritation
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P223Do not allow contact with water
- P231Handle under inert gas
- P261Avoid breathing dust, fume, gas or vapours
- P370In case of fire
- P422
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | -17 °C / 1.4 °F |
| Transport (UN / ADR) | UN 3399 4.3/PG 2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 11-14-19-34-37 |
| Safety statements (S) | 16-26-36/37/39-45 |
| Supplemental hazards | May form explosive peroxides., Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Methylmagnesium chloride solution used for?
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Methylmagnesium chloride solution (CAS: 676-58-4) is primarily used in organic synthesis as a Grignard reagent for carbon-carbon bond formation and for introducing methyl groups into organic molecules. It is a strong base and a potent nucleophile, widely employed in the synthesis of pharmaceuticals, agrochemicals, and other complex organic compounds.
What is the CAS number and chemical formula for Methylmagnesium chloride solution?
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The CAS number is 676-58-4 and the linear formula is CH₃MgCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Methylmagnesium chloride solution at a concentration of 3.0 M in THF. This product is suitable for research and industrial synthesis. TSS does not represent this product as USP, BP, or EP grade.
How should Methylmagnesium chloride solution be handled safely?
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Methylmagnesium chloride solution is highly flammable and reacts violently with water, releasing flammable gases. It causes severe skin burns and eye damage, and may cause respiratory irritation. Handle under an inert atmosphere, away from ignition sources and water. Use appropriate personal protective equipment including face shields, gloves, and respiratory protection.
How is Methylmagnesium chloride solution packed, shipped, and exported?
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This product is classified under UN 3399 and requires specialised packing for flammable liquids that react with water. TSS exports fine chemicals globally, adhering to all relevant international shipping and safety regulations for hazardous materials.
How can I request a quote or sample for Methylmagnesium chloride solution?
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To request a quote or a sample of Methylmagnesium chloride solution, please visit the Tech Serve Solutions website or contact our sales team directly with your inquiry.
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