Methyllithium solution
Methyllithium solution (CAS: 917-54-4, CH3Li, MW: 21.98) is a highly reactive organometallic reagent supplied by TSS. It is a potent base and nucleophile, primarily utilised in organic synthesis for various carbon-carbon bond-forming reactions. Available as a solution in diethoxymethane, this compound requires careful handling due to its pyrophoric and water-reactive nature. It serves as a critical building block in the preparation of complex organic molecules.
- IUPAC
- Lithium methanide,MeLi
Nucleophilic Addition
Methyllithium acts as a strong nucleophile, readily attacking carbonyl groups (aldehydes, ketones, esters) to form new carbon-carbon bonds. This is fundamental in building more complex molecular architectures in pharmaceuticals and fine chemicals.
Deprotonation Reactions
As a powerful base, it is employed for deprotonating weakly acidic protons, generating carbanions or other reactive intermediates. This is crucial for subsequent alkylation or other functionalization steps in multi-step syntheses.
Organic Synthesis Reagent
It is widely used in academic and industrial research for the synthesis of diverse organic compounds, including natural products, agrochemicals, and advanced materials. Its utility lies in its ability to introduce a methyl group or act as a strong base.
| Molecular weight | 21.98 |
|---|---|
| Empirical formula | CH3Li |
| Density | 0.846 g/mL at 25 °C |
| Concentration | 3.1 M in diethoxymethane |
| Storage temperature | 2-8°C |
Hazard statements
- H225Highly flammable liquid and vapour
- H250Catches fire spontaneously if exposed to air
- H260In contact with water releases flammable gases
- H314Causes severe skin burns and eye damage
- H335May cause respiratory irritation
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P222Do not allow contact with air
- P223Do not allow contact with water
- P231Handle under inert gas
- P370In case of fire
- P422
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | -15 °C / 5 °F |
| Transport (UN / ADR) | UN 3399 4.3/PG 1 |
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | F,Xi |
| Risk statements (R) | 11-15-36/37/38 |
| Safety statements (S) | 16-26-43 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Methyllithium solution used for?
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Methyllithium solution is primarily used in organic synthesis as a strong base and nucleophile for carbon-carbon bond formation, deprotonation reactions, and the synthesis of various organic compounds.
What are the CAS number and formula for Methyllithium solution?
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The CAS number for Methyllithium solution is 917-54-4, and its chemical formula is CH3Li.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Methyllithium solution at a concentration of 3.1 M in diethoxymethane. As this is a technical/research grade material, TSS does not represent it as USP, BP, or EP grade.
How should Methyllithium solution be handled and stored?
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Methyllithium solution is highly flammable, pyrophoric, and reacts violently with water. It must be handled under an inert atmosphere (e.g., nitrogen or argon) with appropriate personal protective equipment, including gloves, goggles, and face shields. Store at 2-8°C, away from heat and ignition sources.
How is Methyllithium solution shipped and exported?
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Methyllithium solution is classified under UN 3399, Hazard Class 4.3, Packing Group I, and is shipped and exported by TSS in compliance with all relevant dangerous goods regulations.
How can I request a sample or a quote for Methyllithium solution?
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To request a sample or a quote, please contact the Tech Serve Solutions sales team via our website or by phone, providing your specific requirements and shipping details.
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