Methyl (S)-(−)-2-isocyanato-3-methylbutyrate
Methyl (S)-(−)-2-isocyanato-3-methylbutyrate (CAS 30293-86-8) is a chiral organic building block with the linear formula (CH3)2CHCH(NCO)CO2CH3 and a molecular weight of 157.17 g/mol. This isocyanate derivative is primarily utilised as a precursor in the synthesis of complex molecular scaffolds and bridged azapeptide mimetics, contributing to advancements in medicinal chemistry and organic synthesis.
Synthesis of Molecular Scaffolds
Serves as a key intermediate in the construction of intricate molecular architectures. Its chiral nature is valuable for building complex scaffolds with defined stereochemistry.
Azapeptide Mimetic Development
Used in the preparation of bridged azapeptide mimetics, which are important in drug discovery for their potential to mimic peptide structures with improved stability and bioavailability.
Chiral Building Block
As an asymmetric synthesis precursor, it enables the introduction of specific stereocenters in target molecules, facilitating the creation of enantiomerically pure compounds.
| Molecular weight | 157.17 |
|---|---|
| Linear formula | (CH3)2CHCH(NCO)CO2CH3 |
| Assay | 99% |
| Boiling point | 75 °C/0.04 mmHg(lit.) |
| Density | 1.053 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.428(lit.) |
| Optical activity | [α]20/D −22°, neat |
| Application | Precursor for the synthesis of molecular scaffolds1 and bridged azapeptide mimetics.2 |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 78 °C / 172.4 °F |
| Transport (UN / ADR) | UN 2206 6.1/PG 3 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 23-26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Methyl (S)-(−)-2-isocyanato-3-methylbutyrate used for?
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Methyl (S)-(−)-2-isocyanato-3-methylbutyrate (CAS 30293-86-8) is employed as a precursor for the synthesis of molecular scaffolds and bridged azapeptide mimetics. It is a valuable chiral building block for asymmetric synthesis.
What are the CAS number and linear formula for Methyl (S)-(−)-2-isocyanato-3-methylbutyrate?
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The CAS number is 30293-86-8, and its linear formula is (CH3)2CHCH(NCO)CO2CH3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Methyl (S)-(−)-2-isocyanato-3-methylbutyrate with an assay of 99%. We do not represent this product as USP, BP, or EP grade.
How should Methyl (S)-(−)-2-isocyanato-3-methylbutyrate be handled safely?
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This compound is harmful if swallowed, in contact with skin, or if inhaled, and causes skin and serious eye irritation, and may cause respiratory irritation. Appropriate personal protective equipment, including eyeshields, face shields, gloves, and a suitable respirator, must be used. Handle in a well-ventilated area.
How is Methyl (S)-(−)-2-isocyanato-3-methylbutyrate packed, shipped, and exported?
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Methyl (S)-(−)-2-isocyanato-3-methylbutyrate is packed according to safety regulations for hazardous materials, suitable for export. Shipping details will be provided upon inquiry, adhering to international transport guidelines for chemicals classified under UN 2206.
How can I request a quote or sample for this chemical?
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To request a quote or sample for Methyl (S)-(−)-2-isocyanato-3-methylbutyrate, please contact our sales department through the website or by phone. Provide your contact details and the required quantity.
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