Methyl propiolate
Methyl propiolate (CAS: 922-67-8), with the molecular formula HC≡CCO₂CH₃ and a molar mass of 84.07 g/mol, is a valuable organic building block and ester. This compound, also known as methyl acetylenecarboxylate, is characterised by its propiolate ester structure. It is frequently employed in chemical synthesis for creating complex molecular structures, including polysubstituted acrylate and tetrahydropyrimidin-2-one derivatives, and as a derivatizing agent in analytical chemistry.
- IUPAC
- Methyl acetylenecarboxylate
- Synonyms
- Methyl acetylenecarboxylate
Synthesis of Heterocyclic Compounds
Methyl propiolate serves as a key intermediate in the synthesis of polysubstituted 3-arylaminoacrylate and tetrahydropyrimidin-2-one derivatives, enabling the construction of complex heterocyclic scaffolds.
Thiol Derivatization Agent
In analytical chemistry, methyl propiolate is utilised as a derivatizing agent. It reacts with thiols, facilitating their detection and analysis, particularly in capillary electrophoresis techniques.
Organic Building Block
As a versatile organic building block, methyl propiolate offers a reactive propiolate ester functionality for diverse synthetic transformations in organic chemistry research and development.
| Molecular weight | 84.07 |
|---|---|
| Linear formula | HC≡CCO2CH3 |
| Assay | ≥97.0% (GC) |
| Boiling point | 103-105 °C(lit.) |
| Density | 0.945 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.408(lit.)n20/D 1.409 |
| Application | Methyl propiolate was used in the synthesis of polysubstituted 3-arylaminoacrylate and tetrahydropyrimidin-2-one derivatives1. It was also used as a thiol derivatizing agent for capillary electrophoresis2. |
Hazard statements
- H225Highly flammable liquid and vapour
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 16 °C / 60.8 °F |
| Transport (UN / ADR) | UN 3272 3 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xi |
| Risk statements (R) | 11-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Methyl propiolate used for?
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Methyl propiolate is used in organic synthesis for preparing polysubstituted 3-arylaminoacrylate and tetrahydropyrimidin-2-one derivatives, and as a thiol derivatizing agent in analytical methods like capillary electrophoresis.
What are the CAS number and molecular formula for Methyl propiolate?
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The CAS number for Methyl propiolate is 922-67-8, and its molecular formula is HC≡CCO₂CH₃.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Methyl propiolate with an assay of ≥97.0% (GC). TSS does not represent this product as USP, BP, EP, or other pharmacopoeia grades unless explicitly stated.
How should Methyl propiolate be handled safely?
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Methyl propiolate is a flammable liquid and vapour (H225) and causes skin (H315), eye (H319), and respiratory irritation (H335). Handle with appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator, in a well-ventilated area away from ignition sources.
How is Methyl propiolate packed, shipped, and exported?
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Methyl propiolate is packed according to UN 3272, Class 3, Packing Group II standards for safe transport. Tech Serve Solutions offers global export services.
How can I request a sample or quote for Methyl propiolate?
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To request a sample or a quote for Methyl propiolate, please contact the Tech Serve Solutions sales team via our website or directly by phone.
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