Methyl α-bromoisobutyrate
Methyl α-bromoisobutyrate (CAS 23426-63-3), with the linear formula (CH3)2CBrCOOCH3 and a molar mass of 181.03 g/mol, is a valuable organic building block. This ester is primarily utilised as a reagent in chemical synthesis, particularly in controlled radical polymerization (ATRP) and for preparing complex organic molecules. It serves as a key initiator in polymer science and materials science applications.
- IUPAC
- Methyl 2-bromo-2-methylpropionate
- Synonyms
- Methyl 2-bromo-2-methylpropionate
ATRP Initiator
Methyl α-bromoisobutyrate acts as an effective initiator for Atom Transfer Radical Polymerization (ATRP). This controlled polymerization technique allows for the synthesis of polymers with well-defined architectures, molecular weights, and low polydispersity.
Organic Synthesis
It is employed as a versatile building block in organic synthesis. For instance, it has been used in the Reformatsky reaction to prepare specific cyclic compounds such as 1,4-disubstituted 3,3-dimethylazetidin-2-ones.
Ester Synthesis
As an ester compound containing a reactive bromine atom, it can be utilized in various reactions to introduce the isobutyrate moiety into different molecular frameworks.
| Molecular weight | 181.03 |
|---|---|
| Linear formula | (CH3)2CBrCOOCH3 |
| Assay | ≥99.0% (GC) |
| Density | 1.399 g/mL at 20 °C(lit.) |
| Application | Methyl α-bromoisobutyrate was used in Reformatsky reaction to prepare 1,4-disubstituted 3,3-dimethylazetidin-2-ones1. |
Hazard statements
- H226Flammable liquid and vapour
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 49 °C / 120.2 °F |
| Transport (UN / ADR) | UN 2929 3(6.1) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 10-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Methyl α-bromoisobutyrate used for?
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Methyl α-bromoisobutyrate (CAS 23426-63-3) is primarily used as an initiator for Atom Transfer Radical Polymerization (ATRP) and as a building block in organic synthesis, including applications like the Reformatsky reaction.
What is the CAS number and formula for Methyl α-bromoisobutyrate?
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The CAS number for Methyl α-bromoisobutyrate is 23426-63-3, and its linear formula is (CH3)2CBrCOOCH3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Methyl α-bromoisobutyrate with an assay of ≥99.0% (GC). We do not represent this product as USP, BP, EP, or pharmacopoeia grade.
How should Methyl α-bromoisobutyrate be handled safely?
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Methyl α-bromoisobutyrate is a flammable liquid (flash point 49 °C) and an irritant. Handle with appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator, in a well-ventilated area. Avoid sources of ignition.
How is Methyl α-bromoisobutyrate packed and shipped?
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Tech Serve Solutions can pack and export Methyl α-bromoisobutyrate according to customer requirements and international shipping regulations. Please contact us for specific details.
How can I request a sample or quote for Methyl α-bromoisobutyrate?
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To request a sample or a quote for Methyl α-bromoisobutyrate, please contact our sales team through the website or by phone.
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