(Methoxymethyl)diphenylphosphine oxide
(Methoxymethyl)diphenylphosphine oxide (CAS: 4455-77-0) is a chemical compound with the linear formula (C6H5)2P(O)CH2OCH3 and a molecular weight of 246.24 g/mol. This phosphine oxide derivative is primarily utilised as a catalyst in various organic synthesis reactions, including Pauson-Khand and hydroformylation processes. Its specific chemical structure lends itself to applications requiring precise catalytic activity in fine chemical and pharmaceutical intermediate production.
- IUPAC
- Diphenyl(methoxymethyl)phosphine oxide
- Synonyms
- Diphenyl(methoxymethyl)phosphine oxide

Pauson-Khand Reaction Catalyst
Serves as a catalyst for molybdenum hexacarbonyl-mediated Pauson-Khand reactions, facilitating the synthesis of cyclic ketones.
Hydroformylation Catalyst
Acts as a catalyst in rhodium-catalyzed hydroformylation reactions, a key process for converting alkenes into aldehydes.
Organic Synthesis Reagent
Employed in general organic synthesis, particularly where phosphine oxide functionalities are required for directed reactions or as intermediates.
| Molecular weight | 246.24 |
|---|---|
| Linear formula | (C6H5)2P(O)CH2OCH3 |
| Assay | 98% |
| Application | Catalyst for:• Molybdenum hexacarbonyl-mediated Pauson-Khand reactions1• Rhodium-catalyzed hydroformylation reaction2 |
| Melting point | 115-117 °C(lit.) |

Hazard statements
- H302Harmful if swallowed
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (Methoxymethyl)diphenylphosphine oxide used for?
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(Methoxymethyl)diphenylphosphine oxide is used as a catalyst in reactions such as molybdenum hexacarbonyl-mediated Pauson-Khand reactions and rhodium-catalyzed hydroformylation.
What is the CAS number and chemical formula for (Methoxymethyl)diphenylphosphine oxide?
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The CAS number is 4455-77-0 and the linear chemical formula is (C6H5)2P(O)CH2OCH3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (Methoxymethyl)diphenylphosphine oxide with a minimum purity of 98%. TSS does not represent this product as USP, BP, or EP grade.
How should (Methoxymethyl)diphenylphosphine oxide be handled safely?
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Handle with appropriate personal protective equipment, including a dust mask type N95 (US), eyeshields, and gloves. It is classified as harmful if swallowed (H302).
How is (Methoxymethyl)diphenylphosphine oxide packed and exported?
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This product is carefully packed to ensure stability during transit and is available for global export by Tech Serve Solutions.
How can I request a sample or a quote for (Methoxymethyl)diphenylphosphine oxide?
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To request a sample or a quote, please contact the Tech Serve Solutions sales team through our website or by phone.
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