Mecamylamine hydrochloride
Mecamylamine hydrochloride (CAS: 826-39-1; C11H21N · HCl) is a potent, orally active, non-competitive nicotinic acetylcholine receptor antagonist. With a molecular weight of 203.75 g/mol, this compound acts as a central and peripheral ganglionic blocker. It is primarily recognised for its therapeutic applications, particularly in the management of hypertension and as an aid in smoking cessation. Mecamylamine hydrochloride is supplied by TSS for research and development purposes.
- IUPAC
- 2-(Methylamino)isocamphane hydrochloride,Inversine,N,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine hydrochloride
- Synonyms
- 2-(Methylamino)isocamphane hydrochlorideInversineN,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine hydrochloride
Nicotinic Acetylcholine Receptor Antagonism
Mecamylamine hydrochloride functions as a broad-spectrum antagonist of nicotinic acetylcholine receptors. It inhibits both central and peripheral nicotinic transmission, making it a valuable tool in neuropharmacological research.
Hypertension Management
Historically, mecamylamine hydrochloride has been utilised as an antihypertensive agent. Its mechanism involves blocking ganglionic transmission, leading to a reduction in blood pressure.
Smoking Cessation Aid
The compound has been investigated and used as an aid for smoking cessation by reducing the rewarding effects of nicotine.
Research and Development
As a well-characterised bioactive small molecule, mecamylamine hydrochloride serves as a reagent in cell biology and neuroscience research, particularly in studies involving neurotransmission and ion channels.
| Molecular weight | 203.75 |
|---|---|
| Empirical formula | C11H21N · HCl |
| Solubility | ethanol: soluble122 mg/mLH2O: soluble47 mg/mLisopropanol: soluble476 mg/mLglycerol: soluble95 mg/mL |
Hazard statements
- H301Toxic if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P301IF SWALLOWED
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Mecamylamine hydrochloride used for?
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Mecamylamine hydrochloride is used as a nicotinic acetylcholine receptor antagonist, historically for hypertension management, and as an aid in smoking cessation. It is also employed in research settings for cell biology and neuroscience studies.
What is the CAS number and formula for Mecamylamine hydrochloride?
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The CAS number for Mecamylamine hydrochloride is 826-39-1, and its formula is C11H21N · HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Mecamylamine hydrochloride as a research-grade chemical. We do not represent it as meeting USP, BP, or EP pharmacopoeia standards unless explicitly stated in the product specifications.
How should Mecamylamine hydrochloride be handled safely?
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Mecamylamine hydrochloride is classified as Danger. It is toxic if swallowed and causes skin and serious eye irritation, and may cause respiratory irritation. Recommended personal protective equipment includes a dust mask type N95 (US), eyeshields, faceshields, and gloves. Handle in a well-ventilated area.
How is Mecamylamine hydrochloride packed and shipped?
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Mecamylamine hydrochloride is packed according to safety regulations for hazardous materials, including UN 2811 classification for transport. TSS offers global export services for this chemical.
How can I request a sample or quote for Mecamylamine hydrochloride?
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To request a sample or a quotation for Mecamylamine hydrochloride, please contact our sales department through the website or by phone, providing your specific requirements and delivery details.
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