Lithium amide
Lithium amide (CAS 7782-89-0), with the linear formula LiNH ₂ and a molecular weight of 22.96 g/mol, is a highly reactive inorganic base. It is typically supplied as a white to off-white powder with an assay of 95%. Lithium amide is a potent reagent utilized in various organic synthesis applications, including the preparation of pharmaceuticals, dyes, and complex organic molecules. Its strong basicity makes it valuable for deprotonation reactions and as a catalyst in specific chemical transformations.
Synthesis of Anti-inflammatory Compounds
Lithium amide serves as a key reagent in the synthesis of anti-inflammatory agents and pre-resolving protectin D1, contributing to the development of novel therapeutic compounds.
Preparation of Dipeptidyl Peptidase IV Inhibitors
This compound is employed in the synthetic routes for chemotype dipeptidyl peptidase IV inhibitors, which are important targets in medicinal chemistry research.
Formation of Sterically Congested Triarylamines
Lithium amide facilitates the synthesis of sterically congested triarylamines, a class of compounds with applications in materials science and organic electronics.
Production of Dyes with Large Stokes Shifts
It is used as a reagent in the creation of dyes that exhibit significant Stokes shifts, useful in fluorescent probes and imaging technologies.
Cross-Coupling Reactions
Lithium amide acts as a reagent in cross-coupling reactions, specifically for the coupling of aryl chlorides and amines, enabling efficient C-N bond formation.
| Molecular weight | 22.96 |
|---|---|
| Linear formula | LiNH2 |
| Assay | 95% |
| Form | powder |
| Density | 1.178 g/mL at 25 °C(lit.) |
| Application | Reagent for synthesis of: Antiinflamatory and preoresolving protectin D11 Chemotype dipeptidyl peptidase IV inhibitors2 Sterically congested triarylamines3 Dyes displaying large Stokes shifts4 GM1 ganglioside derivatives5Reagent for cross-coupling of aryl chlorides and amines6 |
| Melting point | 380-400 °C |
Hazard statements
- H261In contact with water releases flammable gas
- H314Causes severe skin burns and eye damage
Precautionary statements
- P231Handle under inert gas
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
- P422
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 1390 4.3 / PGII |
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 14/15-29-34 |
| Safety statements (S) | 26-36/37/39-43-45 |
| Supplemental hazards | Contact with water liberates toxic gas., Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Lithium amide used for?
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Lithium amide (CAS 7782-89-0) is a powerful inorganic base and reagent used in organic synthesis for the preparation of anti-inflammatory compounds, dipeptidyl peptidase IV inhibitors, sterically congested triarylamines, dyes with large Stokes shifts, and in cross-coupling reactions of aryl chlorides and amines.
What are the CAS number and formula for Lithium amide?
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The CAS number for Lithium amide is 7782-89-0, and its linear formula is LiNH ₂.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Lithium amide with an assay of 95%. This product is suitable for laboratory and research purposes. We do not represent this product as USP, BP, EP, or pharmacopoeia grade.
How should Lithium amide be handled safely?
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Lithium amide reacts violently with water, liberating toxic gas and causing severe skin burns and eye damage (H261-H314). Handle with extreme caution in a dry, well-ventilated area, using appropriate personal protective equipment including eyeshields, gloves, and a suitable respirator. Avoid contact with water and moisture.
How is Lithium amide packed and exported by TSS?
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Lithium amide is classified under UN 1390, Hazard Class 4.3, Packing Group II. Tech Serve Solutions ensures secure and compliant packaging for export, adhering to international regulations for hazardous materials.
How can I request a quote or sample for Lithium amide?
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To request a quote or a sample of Lithium amide, please contact our sales team through the website or call us directly. Provide your contact details and the quantity required.
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