LDN193189 hydrochloride

CAS 1062368-24-4 (free base)C25H22N6 · xHClCell Biology

LDN193189 hydrochloride (CAS: 1062368-24-4) is a research chemical with a molecular weight of 406.48 (free base basis). This yellow to orange powder serves as a valuable tool in biological research, particularly within cell signalling and neuroscience. It is commonly employed to investigate apoptosis, cell cycle regulation, and the pathways mediated by bone morphogenetic proteins (BMPs) and their receptors. Its solubility in water further enhances its utility in laboratory settings.

IUPAC: 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline hydrochloride,DM-3189
Synonyms: 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline hydrochloride,DM-3189

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LDN193189 hydrochloride (C25H22N6 · xHCl) — chemical structure, CAS 1062368-24-4 (free base); Life Science, fine chemical supplied by Tech Serve Solutions

Apoptosis and Cell CycleBMPs and ReceptorsCell BiologyCell Cycle ProteinsAntibodies and ReagentsCell Cycle RegulatorsCytokines and Growth FactorsCytokinesGrowth Factors and HormonesKinase/Phosphatase Biology

01 /Applications

Cell Cycle Regulation Studies

LDN193189 hydrochloride is utilised in research to investigate the complex mechanisms of cell cycle progression and regulation. Its role as an inhibitor in certain signalling pathways makes it a key reagent for understanding cell division and proliferation.

BMP Signalling Pathway Investigation

This compound is a potent inhibitor of BMP signalling, making it instrumental in research focused on understanding the roles of BMPs in developmental biology and disease. Researchers use it to dissect the downstream effects of BMP receptor activation.

Apoptosis Research

LDN193189 hydrochloride can be applied in studies examining the induction or modulation of apoptosis (programmed cell death). Understanding its effects helps elucidate cellular survival and death pathways.

Neuroscience Research Applications

Within neuroscience, this chemical can be employed to explore the involvement of BMP signalling in neuronal development and function. It serves as a probe for investigating cell signalling in the nervous system.

02 /Properties

Molecular weight	406.48 (free base basis)
Empirical formula	C25H22N6 · xHCl
Assay	≥98% (HPLC)
Form	powder
Colour	yellow to orange
Solubility	H2O: soluble5 mg/mL, clear (warmed)
Storage temperature	−20°C

03 /Identifiers & registry

CAS number

1062368-24-4 (free base)

04 /Additional specifications

Shipped In	wet ice
Storage Condition	desiccated

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is LDN193189 hydrochloride used for?

LDN193189 hydrochloride is primarily used as a research chemical to study cell cycle regulation, apoptosis, BMP signalling pathways, and in neuroscience research.

What are the CAS number and formula for LDN193189 hydrochloride?

The CAS number for the free base is 1062368-24-4, and the empirical formula is C25H22N6 · xHCl. The molecular weight, on a free base basis, is 406.48.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies LDN193189 hydrochloride with an assay of ≥98% (HPLC). This product is intended for research purposes and is not represented as USP, BP, EP, or pharmacopoeia grade.

How should LDN193189 hydrochloride be handled and stored?

LDN193189 hydrochloride is classified under WGK Germany 3, indicating it is hazardous. It should be stored desiccated at -20°C. Handle with appropriate personal protective equipment in a well-ventilated area.