Lactacystin

CAS 133343-34-7C15H24N2O7SBiochemicals & Reagents

Lactacystin (CAS: 133343-34-7) is a bioactive small molecule with the empirical formula C15H24N2O7S and a molecular weight of 376.43 g/mol. It is recognised as a potent and selective proteasome inhibitor. Lactacystin is extensively utilised in cell biology research to investigate intracellular protein degradation pathways and cellular signalling mechanisms, particularly in relation to endoplasmic reticulum stress.

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Lactacystin (C15H24N2O7S) — chemical structure, CAS 133343-34-7; Life Science, fine chemical supplied by Tech Serve Solutions

Application IndexBioactive Small MoleculesBiochemicals and ReagentsCell BiologyCell Signaling EnzymesEndoplasmic Reticulum StressEnzyme InhibitorsEnzyme Inhibitors by EnzymeEnzymesInhibitors

01 /Applications

Proteasome Inhibition Studies

Lactacystin serves as a crucial tool for researchers studying the ubiquitin-proteasome system. Its ability to inhibit the proteasome allows for the investigation of protein turnover and its impact on cellular processes.

Cellular Signalling Research

This compound is employed to explore the role of proteasome activity in various cell signalling pathways. It aids in understanding how protein degradation influences cellular responses, including those related to stress and differentiation.

Endoplasmic Reticulum Stress Investigation

Researchers use Lactacystin to examine the mechanisms of endoplasmic reticulum (ER) stress and the unfolded protein response (UPR). It helps elucidate the consequences of impaired protein degradation on ER function.

Biochemical Research Reagent

As a biochemical reagent, Lactacystin is valuable for in vitro and in vivo studies requiring specific inhibition of proteasome activity. Its selectivity makes it a reliable choice for experimental design.

02 /Properties

Molecular weight	376.43
Empirical formula	C15H24N2O7S
Assay	≥90% (HPLC)
Storage temperature	−20°C

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

133343-34-7

MDL number

MFCD01076525

PubChem substance

24896445

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Lactacystin used for?

Lactacystin is primarily used in research for studying proteasome inhibition, intracellular protein degradation, cell signalling, and endoplasmic reticulum stress.

What are the CAS number and chemical formula for Lactacystin?

The CAS number for Lactacystin is 133343-34-7, and its empirical formula is C15H24N2O7S.

What grade and purity does Tech Serve Solutions supply for Lactacystin?

Tech Serve Solutions supplies Lactacystin with an assay of ≥90% (HPLC). This product is intended for research and laboratory use and is not represented as USP, BP, EP, or any other pharmacopoeia grade.

How should Lactacystin be handled and stored?

Lactacystin should be handled using appropriate personal protective equipment, including eyeshields, gloves, and a P1 (EN143) or N95 (US) respirator filter. It should be stored at -20°C.

Is Lactacystin a hazardous substance?

Yes, Lactacystin is classified with a WGK Germany rating of 3, indicating it is a substance hazardous to the aquatic environment.

How is Lactacystin shipped?

Lactacystin is packed and shipped according to standard chemical handling procedures, often with special consideration for its storage temperature requirement of -20°C. TSS is a global supplier and exporter.